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Diss Factsheets
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EC number: 273-195-5 | CAS number: 68953-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 04 Mar - 11 Mar 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP - Guideline study, tested with the source substance CAS 67701-08-0. In accordance to the ECHA guidance document "Practical guide 6: How to report read-across and categories (March 2010)", the reliability was changed from RL1 to RL2 to reflect the fact that this study was conducted on a read-across substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Fatty acids, C16-18 and C18-unsatd.
- EC Number:
- 266-932-7
- EC Name:
- Fatty acids, C16-18 and C18-unsatd.
- Cas Number:
- 67701-08-0
- IUPAC Name:
- 67701-08-0
- Details on test material:
- - Name of test material (as cited in study report): Edenor Ti dest. (FS010)
- Physical state: white wax
- Analytical purity: no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Kleinrussen Chbb:Hm
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Thomae, Biberach, Germany
- Age at study initiation: adults
- Sex: male
- Identification: ear tag and cage signs
- Weight at study initiation: mean 2297.5 g
- Housing: individually in rabbit battery (Heinkel, 7343 Kuchen, Germany)
- Diet (e.g. ad libitum): Altromin-Haltungsdiät 2023 (Altromin GmbH, Lage, Germany); ad libitum
- Water (e.g. ad libitum): tap water; ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 21
- Humidity (%): 45 - 55
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 g
- Preparation: made liquid by slight heating - Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- 3 d
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- SCORING SYSTEM:
Acc. to 79/831/EWG, Annex V, Part B:
Cornea:
0 – No ulceration or opacity
1 – Scattered or diffuse areas of opacity (other than slight dulling of normal luster), details of iris clearly visible
2 - Easily discernible translucent area; details of iris slightly obscured
3 - Nacreous area; no details of iris visible; size of pupil barely discernible
4 - Opaque cornea; iris not discernible through the opacity
Iris:
0 – Normal
1 - Markedly deepened rugae, congestion, swelling, moderate circumcorneal hyperaemia;
or injection; iris reactive to light (a sluggish reaction is considered to be an effect
2 - Haemorrhage, gross destruction, or no reaction to light
Conjunctivae
Erythema
0 – Normal
1 - Some blood vessels hyperaemic (injected)
2 - Diffuse, crimson colour; individual vessels not easily discernible
3 - Diffuse beefy red
Chemosis
0 – Normal
1 - Some swelling above normal
2 - Obvious swelling, with partial eversion of lids
3 - Swelling, with lids about half closed
4 - Swelling, with lids more than half closed
TOOL USED TO ASSESS SCORE: Fluorescein
ca. 24 h prior to application, 0.1 ml of a 0.5 % Fluorescein solution was instilled into the eyes and washed out 20 sec later to detect corneal damage.
24 h after instillation of the test substance, 0.1 ml of a 0.5 % Fluorescein solution was instilled into the eyes and washed out after 20 seconds to detect corneal damage.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: mean 24 - 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: mean 24 - 72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no effects
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: mean 24 - 72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: mean 24 - 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 6 h
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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