Tetrahydrothiopyran-3-carboxaldehyde

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well documented study report, comparable to guideline

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

Inhalation risk (hazard) test

GLP compliance:

no

Test type:

fixed concentration procedure

Limit test:

no

Test material

Reference

Name:

Unnamed

Type:

Constituent

Details on test material:

- Name of test material (as cited in study report): 3.4.5.6-Tetrahydro-2H-Thiopyran-3-Carboxyaldehyd
- Substance No.: 85/486
- Analytical purity: no data
- Date of manufacture: 27.05.86
- Stability under storage conditions: at least for two month
- Storage condition of test material: 4° C
- no further data

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach, Germany
- Strain/quality: SPF-Wistar/Chbb:THOM
- Age at study initiation: 8 weeks
- Weight at study initiation: mean weight males: 245 g; females: 174 g
- Fasting period before study: none
- Housing: 3 per cage in stainless steel cages
- Diet: Kliba-Labordiaet 343 rat mouse, Klingenthalmuehle AG, Kaiseraugst, Switzerland ad libitum
- Water: Tap water 250 ml/day and cage
- Acclimation period: at least 5 days


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

7 h

Concentrations:

a mean substance concentration of 0.64 mg/ l air was calculated over the whole exposure period

No. of animals per sex per dose:

3 males and 3 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: at least once daily, several times on the day of exposure
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

0.64 mg/L air (nominal)

Exp. duration:

7 h

Mortality:

no death occurred

Clinical signs:

other: During the exposure: muzzling, attempts to escape, irregular respiration, lacrimation After the exposure: no clinical signs noted, animals were free of symptoms

Body weight:

nothing abnormal reported

Gross pathology:

nothing abnormal detected