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Diss Factsheets
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EC number: 468-890-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to OECD 207 under China GLP regulation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- China GLP regulation
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Test material form:
- liquid: viscous
- Details on test material:
- Chemical name: 2-(4-Hydroxy-3,5-dimethoxy-benzylidene)-malonic acid bis-(2-ethyl-hexyl) ester
CAS No.: 444811-29-4
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- no
- Details on preparation and application of test substrate:
- The test item was directly added into the soil. A total amount of 10 g mixture of the test item and dry soil was prepared (premix). Then the premix was added to 540 g soil (dry weight) for each test container. The medium was throughly mixed and deionised water was added to give an overall moisture content of about 35 %.
Test organisms
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- The test organisms were obtained from a eartworm farm in Nanjing, China
Study design
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- yes
- Total exposure duration:
- 14 d
Test conditions
- Test temperature:
- 20 - 22°C
- pH:
- 6.2 - 6.5
- Moisture:
- 30 - 36 %
- Nominal and measured concentrations:
- 1000 mg/kg (dry weight of soil)
- Reference substance (positive control):
- yes
- Remarks:
- 2-chloracetamide
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil ww
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/kg soil ww
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- behaviour
- Details on results:
- No mortality were observed in worms exposed to the test item at a limit concentration of 1000 mg/kg soil ww during the 14-day exposure period.
- Results with reference substance (positive control):
- The LC50 0f 2-chloroacetamide to Eisenia fetida was 25.1 mg/kg (dry soil) after 14 days of exposure.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test item did not induce any toxicity to earthworms exposed to the limit concentration of 1000 mg/kg soil over a period of 14 days.
- Executive summary:
The acute toxicity of the substance to adult earth worm (Eisenia fetida) was investigated in an artificial soil test according to OECD No. 207. Artificial soil was used as the test medium. The moisture content of the test medium during the course of the study was between 30 and 36% and the pH was between 6.2 and 6.5. The earth worms were exposed to a limit dose of 1000 mg/kg dry weight soil for a period of 14 days at defined temperature (20 - 22°C), humidity (80 to 85%) and under continuous light (400 to 800 lux). Each group (control and treatment group) consisted of 4 replicates with 10 worms each. No lethality was observed during the 14 -day observation period neither in the control nor in the limit treatment group. Based on the results of this study, the LC50 of the test substance exceeded 1000 mg/kg dry soil. This concentration can be considered as the NOEC as no adverse effects have been observed in the treatment group.
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