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EC number: 482-140-6 | CAS number: 13641-96-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 December 2003 - 4 February 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection: 2nd December 2002, Date of signature: 13th February 2003
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 482-140-6
- EC Name:
- -
- Cas Number:
- 13641-96-8
- Molecular formula:
- Hill formula: C6 H7 N O3 CAS formula: C6 H7 N O3
- IUPAC Name:
- 2-isocyanatoethyl prop-2-enoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl: CD (SD) IGS BR
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd. Margate, Kent, UK.
- Age at study initiation: 8-12 weeks
- Weight at study initiation: within an interval of ±20% of mean initial bodyweight
- Fasting period before study: overnight immediately before and 3-4 hours after dosing
- Housing: Groups of three in suspended solid-floor polypropylene cages furnished with woodflakes.
- Diet (e.g. ad libitum): Certified Rat and Mouse Diet (Code 5LF2) supplied by BCM IPS Limited, London, UK; ad libitum
- Water (e.g. ad libitum): Mains dinking water; ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25
- Humidity (%):30-70
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Arachis oil BP
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 30 and 5 mg/mL, respectively
- Amount of vehicle (if gavage): volume administered to each animal calculated according to the fasted bodyweight at time of dosing
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: All available information on the toxicity of the test material - Doses:
- 300 and 50 mg/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: death and overt signs of toxicity: 30 min, 1, 2, and 4 hours after dosing and subsequently once daily; weighing after 7 and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, external examination and opening of the abdominal and thoracic cavities for examination of major organs; macroscopic abnormalities were recorded
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 200 - 300 mg/kg bw
- Mortality:
- 300 mg/kg:
1st step: 3/3 (after 2h)
2nd step: 1/3 (after 1d)
50 mg/kg: 0/6 - Clinical signs:
- other: Signs of systemic toxicity noted in animals treated at a dose level of 300 mg/kg were hunched posture, lethargy, ataxia and decreased respiratory rate. One animal treated at a dose level of 300 mg/kg appeared normal throughout the study. There were no
- Gross pathology:
- Effects on organs: Abnormalities noted at necropsy of animals that died during the study were abnormally red lungs, dark liver or patchy pallor of the liver, dark kidneys and slight haemorrhage of the gastric mucosa. Raised white foci on the non-glandular region of the stomach were noted at necropsy of two animals treated with 50 mg/kg. No abnormalities were noted at necropsy of all other animals that were killed at the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- other: Acute Tox. 3 (H301) according to CLP Regulation (EC) No 1272/2008.
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