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EC number: 411-950-4 | CAS number: 96562-58-2 DHPPME; MAK-ME; MEHPOPS; R-MAQ-ME
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral Route: Under the conditions of this study, the 28 day No Observable Adverse Effect Level was 1000 mg/kg/day (males and females).
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Only one study is available; it was conducted in accordance with standardised guidelines under GLP conditions and was assigned a reliability score of 1 in accordance with the criteria of Klimisch et al. (1997). The quality of the database is therefore considered to be good.
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Oral Route
The potential for the test material to cause repeated dose toxicity was investigated in accordance with the standardised guidelines OECD 407 and EU Method B.7 under GLP conditions.
Four groups of 6 male and 6 female Sprague-Dawley rats received the test material daily by gavage for 4 weeks at doses of 0 (control), 15, 150 or 1000 mg/kg/day. The vehicle was aqueous methylcellulose at 1 %. The animals were checked at intervals each day for clinical signs and mortality. Food consumption was measured weekly during the treatment period and body weights were determined weekly from allocation to experimental groups throughout to termination. Haematological and blood biochemistry investigations were performed on day 28. On day 30, all the animals were sacrificed and a macroscopic examination performed. Designated organs were weighed and a range of tissues preserved for microscopic examination.
Ptyalism was observed from day 2 or 3 of treatment in all males and females given 1000 mg/kg/day. This clinical sign was considered to be treatment-related. No mortalities occurred during the course of the study. The food consumption and body weight gain of all treated groups was similar to that of respective controls during the study. There were no treatment related findings among the haematological parameters. A slightly lower plasma inorganic phosphorus concentration was observed in males given 1000 mg/kg/day, with a slightly higher plasma triglyceride concentration in males of the same group. These findings were considered to be treatment-related. There were no treatment-related effects on the weights of those organs determined. None of the macroscopic and microscopic findings noted were considered to be treatment-related.
The daily oral administration of the test material to rats for 4 weeks at doses of 15, 150 or 1000 mg/kg/day was well tolerated inducing at 1000 mg/kg/day only ptyalism and minor changes in plasma inorganic phosphorus and triglyceride concentrations. In isolation, these effects are of doubtful toxicological importance. The No Observable Effect Level is 150 mg/kg/day but the No Observable Adverse Effect Level of the test material is 1000 mg/kg/day.
Under the conditions of this study, the No Observable Adverse Effect Level was 1000 mg/kg/day (males and females).
Justification for classification or non-classification
In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No 1272/2008, the substance does not require classification with respect to repeated dose toxicity via the oral route.
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