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EC number: 246-805-2 | CAS number: 25306-75-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- other: published data
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Justification for type of information:
- Carbon disulphide is both a reagent in the manufacture, as well as a decomposition product of xanthates. SIBX readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of SIBX.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- GLP compliance:
- yes
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Test organisms (species):
- Chlorella pyrenoidosa
- Details on test organisms:
- SPECIES #
(NAME): 426 Chlorella pyrenoidosa (Green Algae)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: 10E+8 CELLS/100 ML - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 90 mg CaCO3/L
- Test temperature:
- 20 ± 1 °C
- pH:
- 8.7 ± 0.2
- Dissolved oxygen:
- NR
- Salinity:
- NR
- Details on test conditions:
- The test was carried out in sealed flasks to prevent evaporation of CS2.
The medium contained major salts, urea, Ca-glycerophosphate, dextrose and trace elements. The complete composition of the test medium is given in Van Leeuwen and Maas, Environ. Pollution A37: 105-115 (1985).
The starting density of the cells was 1E5 cells/mL. The volume of test medium was 100 mL per flask. The medium was shaken under fluorescent light (7.5 W/m2). - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 21 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 47.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: On a molecular weight scaled basis, the EC50 would be 47.5 mg/l. (21 x 172.24) /76.13 =47.5 mg/l
- Details on results:
- Carbon disulphide is both a reagent in the manufacture, as well as a decomposition product of xanthates. Reaction mass of SIBX readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of Reaction mass of SIBX.
On a molecular weight scaled basis, the EC50 would be 47.5 mg/l.
(21 x 172.24) /76.13 =47.5 mg/l - Reported statistics and error estimates:
- no data
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96-h EC50 of CS2 for the alga Chlorella pyrenoidosa in sealed flasks was 21 mg/L, based on the inhibition of growth rate.
Carbon disulphide is both a reagent in the manufacture, as well as a decomposition product of xanthates. SIBX readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of SIBX.
On a molecular weight scaled basis, the EC50 would be 47.5 mg/l. (21 x 172.24) /76.13 =47.5 mg/l - Executive summary:
Carbon disulphide is both a reagent in the manufacture, as well as a decomposition product of xanthates. Reaction mass of SIBX readily decomposes to carbon disulphide, especially in the presence of moisture/water. Therefore, the health effects of carbon disulphide (CS2) need to be considered in the assessment of Reaction mass of SIBX. On a molecular weight scaled basis, the EC50 would be 47.5 mg/l. (21 x 172.24) /76.13 =47.5 mg/l
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction:US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR model
- Principles of method if other than guideline:
- ECOSAR Program(v1.00)
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- other: QSAR model
- Details on test organisms:
- not applicable. QSAR model
- Test type:
- other: QSAR model
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Nominal and measured concentrations:
- not applicable. QSAR model
- Details on test conditions:
- 100% sodium O-isobutyl dithiocarbonate
SMILES : O(C(CC)C)C(S([Na]))=S
CHEM : Carbonodithioic acid, o-(2-methylpropyl) ester, sodium salt
CAS Num: 25306-75-6
MOL FOR: C5 H9 O1 S2 Na1
MOL WT : 172.24
Log Kow: 1.78 (used)
Wat Sol: 663 mg/L (measured) - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 48.819 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 17.983 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- not specified
- Remarks on result:
- other: NOEC cited as a ChV value
- Details on results:
- Green Algae, 96-hr EC50 = 48.819mg/L (ppm)
Green Algae, 30-day, NOEC cited as a ChV value = 17.983 mg/L(ppm) - Validity criteria fulfilled:
- yes
- Remarks:
- method for chemicals properties assessment.
- Conclusions:
- Green Algae, 96-hr EC50 = 48.819 mg/L (ppm)
Green Algae, 30-day, NOEC cited as a ChV value = 17.983 mg/L(ppm) - Executive summary:
The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 17.983 mg/L (ppm) Green Algae.
The ECOSAR QSAR model predicts that 96-hr EC50 value would to be 48.819 mg/L (ppm) for Green Algae.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Justification for type of information:
- 2-methylpropan-1-ol /Isobutyl alcohol/ is both reagents used in the manufacture of sodium O-isobutyl dithiocarbonate . Therefore, 2-methylpropan-1-ol /Isobutyl alcohol/ need to be considered in the assessment of sodium O-isobutyl dithiocarbonate
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38412, Part 9
- Principles of method if other than guideline:
- Cell multiplication inhibition test
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- Scenedesmus suspicatus (SAG 8681)
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- NR
- Test temperature:
- 24 0C
- pH:
- 8.0 to 9.3
- Dissolved oxygen:
- NR
- Salinity:
- NR
- Nominal and measured concentrations:
- Concentration range: 80-10000 mg/L
- Details on test conditions:
- Extinction was measured at 578nm
- Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 230 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1 250 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- A 48h EC50 of 230 mg/L has been determined for the effects of the test substance (Isobutyl Alcohol ) on growth rate of the
Scenedesmus suspicatus
Isobutyl Alcohol is both reagents used in the manufacture, as well as decomposition products of xanthates. - Validity criteria fulfilled:
- yes
- Conclusions:
- A 48h EC50 of 230 mg/L has been determined for the effects of the test substance (Isobutyl Alcohol ) on growth rate of the
Scenedesmus suspicatus
Isobutyl Alcohol is both reagents used in the manufacture, as well as decomposition products of xanthates.
Referenceopen allclose all
Overview of QSARs estimations on aquatic toxicity of SIBX to Green algae
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
Green Algae,96-hr EC50 = 48.819 mg/L (ppm)
Green Algae, 30-day, ChV (chronic value) =17.983 mg/L(ppm)
|
Reliable with restrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
Green Algae, 96-hr EC50 = 48.819mg/L (ppm)
Green Algae, 30-day, NOEC cited as a ChV value = 17.983 mg/L(ppm)
Description of key information
The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 17.983 mg/L (ppm) Green Algae.
The ECOSAR QSAR model predicts that 96-hr EC50 value would to be 48.819 mg/L (ppm) for Green Algae.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 48.819 mg/L
- EC50 for marine water algae:
- 4.88 mg/L
- EC10 or NOEC for freshwater algae:
- 17.983 mg/L
- EC10 or NOEC for marine water algae:
- 1.8 mg/L
Additional information
The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 17.983mg/L (ppm) Green Algae.
The ECOSAR QSAR model predicts that 96-hr EC50 value would to be 48.819mg/L (ppm) forGreen Algae.
The available data for saltwater algae and cyanobacteria are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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