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EC number: 410-940-7 | CAS number: 60166-91-8 LACTOFTALURO
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- (S)-5-[2-(acetyloxy)propanamido]-2,4,6-triiodo-1,3-di(chloroformyl)benzene
- EC Number:
- 410-940-7
- EC Name:
- (S)-5-[2-(acetyloxy)propanamido]-2,4,6-triiodo-1,3-di(chloroformyl)benzene
- Cas Number:
- 60166-91-8
- Molecular formula:
- C13H8Cl2I3NO5
- IUPAC Name:
- 1-{[3,5-bis(carbonochloridoyl)-2,4,6-triiodophenyl]carbamoyl}ethyl acetate
- Test material form:
- solid: particulate/powder
1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Remarks:
- Crl:CD(SD)BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The Sprague Dawley rat was chosen as a rodent species since it is widely accepted by Health Authorities as an experimental model with documented susceptibility to a wide range of toxic substances.
Number and sex:
5 males + 5 females/group
Body weight (on receipt):
Males: 225 - 250 g
Females: 200 - 225 g
Age (on receipt):
about 7-9 weeks
Supplier:
harles River Italia S.p.A.
Via Indipendenza, 11
22050 - CALCO (Como)
Shipping slip No. 00485 dated Jan. 17, 1992.
Acclimation:
about one week before the start of the test. Animals were observed daily to ascertain their fitness for the study.
Housing:
5 animals/sex/cage in air-conditioned rooms.
- Temperature: 22 ° C ± 2
- Relative humidity: 55% ± 10
- Air changes: about 20/hour filtered on HEPA 99.97%.
- Light: 12 hour cycle (7 a.m. - 7 p.m.)
- Cage size: grill cages 40.5x38.5x18h cm with stainless feeder. The waste that dropped through the grill bottom on removable paper was periodically disposed of.
Animal identification:
by nicks or tippings of the outer ear. Cage card gave experiment number, dosage group and date of administration.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Methylcellulose (400 cps) 0.5% in water
- Details on oral exposure:
- Single administration
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 males + 5 females per seg per dose
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- None
- Clinical signs:
- other: Signs of toxicity related to dose levels: At this limit dose administered neither clinical signs nor modifications of body weight gain were observed in the 14 day observation period.
- Gross pathology:
- Effects on organs:
Autoptic examination on all animals at the end of the
observation period showed no gross modifications of the
various organs examined.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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