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EC number: 605-460-1 | CAS number: 167004-78-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 24 February 1987
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Phosphinic acid, P-[3-(acetyloxy)-3-cyanopropyl]-P-methyl-, butyl ester
- EC Number:
- 605-460-1
- Cas Number:
- 167004-78-6
- Molecular formula:
- C11 H20 N O4 P
- IUPAC Name:
- Phosphinic acid, P-[3-(acetyloxy)-3-cyanopropyl]-P-methyl-, butyl ester
- Details on test material:
- Molecular weight: 261 g/mol
Molecular formular: C11H2ONO4P
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source (i.e. manufacturer or supplier) and lot/batch number of test material: supplied by the sponsor; batch number CR 21422/01/940801
- Purity, including information on contaminants, isomers, etc.: 90 % (w/w)
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: -10°C (+-5°C) in the dark
- Solubility and stability of the test material in the solvent/vehicle and the exposure medium: The stability of the test material in the vehickle was confirmed over the dosing period
- Reactivity of the test material with the incubation material used (e.g. plastic ware): not determined
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River UK Ltd., Manston Road, Margate, Kent, UK
- Age at study initiation: 6 weeks
- Weight at study initiation: males: approx. 155 g (141-178 g); females: approx. 170 g (154-184 g)
- Fasting period before study: overnight prior to dosing.
- Housing: polycarbonate cages with mesh floors.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): Domestic quality tap water was supplied ad libitum.
- Acclimation period: 1 or 2 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): between 19 and 23°C
- Humidity (%): between 45 and 65%.
- Photoperiod (hrs light): 12 hours per day
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- The test material was administered by gavage as a suspension in sesame oil at a constant volume of 10 ml/kg body weight. Dose levels were based on the results of a preliminary rangefinding and on the findings resulting from dosing males at 450 and 900 mg/kg body weight.
- Doses:
- females: 0, 112.5, 225 or 450 mg/kg body weight
males: 0, 112.5, 225, 450 and 900 mg/kg body weight - No. of animals per sex per dose:
- males: 5; females: 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Body weights were recorded immediately prior to treatment (except for control females) and 7 and 14 days after dosing.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
- Preliminary study:
- All males treated with 450 and 900 mg test material/kg and 1 male treated at 225 mg test material/kg died immediately after dosing. Three females treated with 450 mg/kg and 2 females treated with 225 and 112.5 mg/kg also died on the day of dosing within 10-20 minutes.
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 277 mg/kg bw
- 95% CL:
- 210 - 366
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 253 mg/kg bw
- 95% CL:
- 100 - 639
- Mortality:
- All males treated with 450 and 900 mg test material/kg and 1 male treated at 225 mg test material/kg died immediately after dosing. Three females treated with 450 mg/kg and 2 females treated with 225 and 112.5 mg/kg also died on the day of dosing within 10-20 minutes.
- Clinical signs:
- other: Clinical signs were noted in all males treated at 112.5 and 225 mg/kg and in all treated females. In each animal the onset of the first clinical sign was rapid {c. 5-12 minutes). The principal clinical signs which were non-specific and seen in the majorit
- Gross pathology:
- Dark livers with pale areas were noted in 5/5 males treated at 450 mg/kg and 2/5 males treated at 900 mg/kg.
No macroscopic abnormalities were detected.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Under the evaluated conditions the LD50 was determined at 253 (females) and 277 mg/kg bw, warranting a classification as acute oral tox Cat. 3 (H301) according to CLP (EG) No. 1272/2008.
- Executive summary:
The acute oral LD50 value (with 95% confidence limits) of test substance in the rat were :
Males : 277 (210-366) mg/kg body weight
Females : 253 (100-639) mg/kg body weight
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