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Diss Factsheets
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EC number: 701-439-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
No genetic toxicity studies with Reaction mass of cobalt olivine and crystalline silicon dioxide are available, thus the genetic toxicity will be addressed with existing data on the relevant toxic unit cobalt. The source information is taken from the Cobalt REACH Consortium dossier for genetic toxicity in which all available information is given for in vitro and in vivo genetic toxicity. Further details are given in the source endpoint summary.
Additional information
The genetic toxicity of Reaction mass of cobalt olivine and crystalline silicon dioxide is addressed with existing data on the source substances identified in the read-across of the cobalt category substances as defined by the Cobalt REACH Consortium.
Based on the approach for the genetic toxicity for the cobalt category substances, the pigment Reaction mass of cobalt olivine and crystalline silicon dioxide is also a member of that category, thus unrestricted read-across to the CoRC data is made.
The relevant information is given in the source study records and are discussed in the source endpoint summary and are not repeated here for the sake of brevity.
Justification for classification or non-classification
The hazard conclusion for Reaction mass of cobalt olivine and crystalline silicon dioxide for the endpoint germ cell mutagenicity is adopted from the cobalt category substances, based on the read-across approach as outlined in the report attached to section 13.
Based on the entire database of genetic toxicity studies and the review by the OECD and an external peer reviewer it is concluded that in summary, poorly soluble cobalt salts/compounds do not appear to be genotoxic in vitro or in vivo at all, soluble cobalt salts do not elicit any mutagenic activity either in bacterial or mammalian test systems. However they induce some genotoxic effects in vitro, mainly manifest as DNA strand or chromosome breaks, which are consistent with a reactive oxygen mechanism, as has been proposed by various authors. A weight-of-evidence approach was applied, considering positive as well as negative in vivo clastogenicity studies and the absence of such chromosome damage in humans that are occupationally exposed to inorganic cobalt substances. It was concluded that effective protective processes exist in vivo to prevent genetic toxicity with relevance for humans from the soluble cobalt salts category (OECD 2014, Kirkland et al. 2015).
Based on the above information, the classification criteria for germ cell mutagenicity according to regulation (EC) 1272/2008 are not met, thus no classification required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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