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Diss Factsheets
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EC number: 217-199-7 | CAS number: 1772-25-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019.11.08-2020.1.10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
- Vehicle:
- no
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow Trout
- Source:Trout Lodge Trout Farm (Sumner, WA)
- Age at study initiation (mean and range, SD):Junvenile, 40days
- Length at study initiation (length definition, mean, range and SD):34±4mm
- Weight at study initiation (mean and range, SD):0.4263±0.12g
ACCLIMATION
- Acclimation period:12days
- Acclimation conditions (same as test or not):same
- Type and amount of food during acclimation:not specified
- Feeding frequency during acclimation:daily
- Health during acclimation (any mortality observed): NA - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 80 mg/L CaCO3
- Test temperature:
- 11℃
- pH:
- 7.7
- Dissolved oxygen:
- 100 mg/L
- Conductivity:
- 3.13.9-3.15-8 μmhos/cm
- Nominal and measured concentrations:
- 1000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:EC chamber C
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: 2 gallon glass aquaria
- Aeration: no
- Type of flow-through (e.g. peristaltic or proportional diluter): static
- Renewal rate of test solution (frequency/flow rate):no
- No. of organisms per vessel:10
- No. of vessels per concentration (replicates):3
- No. of vessels per control (replicates):3
- No. of vessels per vehicle control (replicates):10
- Biomass loading rate:1 g fish/L
TEST CONCENTRATIONS
- Range finding study: 0.1, 1, 10, 50, and 100 mg/L
- Test concentrations: 100 mg/L
- Results used to determine the conditions for the definitive study: limit test concentration from OECD203 - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- yes
- Conclusions:
- The NOEC of Tricyanohexane was determined to be 100mg/L, and the LC50 was determined to be >100mg/L.
- Executive summary:
This study was conducted to assess the toxicity of the test substance,Tricyanohexane, to rainbow trout,Oncorhynchus mykiss,in a 96-hour static test.
Test concentrations were determined by preliminary range-finding test. The range-finder indicated aLC5o (Median Lethal Concentration) of>100 mg/L, so a limit test was conducted in lieu of a definitive.The limit test was conducted using the test substance at a concentration of 100 mg/L and was administered to the fest system, Oncorhynchus mykiss, in moderately hard synthetic freshwater. Three replicates of ten organisms each were treated. A control group containing three control replicates often organisms was not exposed to the test substance.Dissolved oxygen, temperature, conductivity and pH measurements were recorded at dosing and termination.Observations for survival in each test chamber were made daily.The test was terminated after 96± 1 hours of exposure. A mortality rate of 0.00% was observed in the control and organisms treated with 100 mgL. Therewere no observable abnormalities in either group.The No Observed Effect Concentration (NOEC) of Tricyanohexane was determined to be 100 mg/L, and the Median Lethal Concentration (LC50) was determined to be > 100mg/L.Results presented are based on nominal concentrations.
Reference
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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