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EC number: 236-283-4 | CAS number: 13280-60-9
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 August - 11 September 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- EC No. 440/2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- 5-amino-2-nitrobenzoic acid
- EC Number:
- 236-283-4
- EC Name:
- 5-amino-2-nitrobenzoic acid
- Cas Number:
- 13280-60-9
- Molecular formula:
- C7H6N2O4
- IUPAC Name:
- 5-amino-2-nitrobenzoic acid
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- Oxidane
- Reference substance name:
- Unknown impurities.
- Molecular formula:
- Not available as unknown impurities.
- IUPAC Name:
- Unknown impurities.
- Test material form:
- solid
- Details on test material:
- Batch / Lot No. 10044431
Constituent 1
impurity 1
impurity 2
- Specific details on test material used for the study:
- Batch No.: 10044431
Storage Conditions: Room temperature (approx. 15 to 25 °C)
Results and discussion
Melting / freezing point
- Key result
- Melting / freezing pt.:
- 249.5 °C
- Atm. press.:
- 1 004.3 hPa
- Decomposition:
- yes
- Decomp. temp.:
- ca. 250 °C
Any other information on results incl. tables
During the heating phase a distinct endothermic effect was observed in the temperature range of 240 – 250 °C, which can be assigned to the melting of the test item. The endothermic effect was directly followed by an exothermic effect starting at a temperature of approx. 250 °C with an average decomposition energy of -750 J/g.
| No. | Sample weight (mg) | Onset of effect (°C) | Range of effect (°C) | Weight loss (mg) | Atmospheric pressure (hPa) |
| PN18264 |
9.44 | 249.65 | 240 - 250 (endo) 250 - 320 (exo) |
5.04 | 1004.3 |
| PN18265 | 10.58 | 249.26 | 240 - 250 (endo) 250 - 320 (exo) |
4.69 |
1004.3 |
As the onset temperatures in both tests deviate by less than 0.5 K from their mean value of 249.46 °C, this temperature can be used as melting point. The test item has a melting point of 249.5 °C accompanied by its decomposition.
Optical verification using the capillary method
To verify the results of the DSC measurement, an additional measurement in a melting capillary was performed in the temperature range of 200 °C to 260 °C with a heating rate of 10 K/min. Starting at a temperature of 240 °C change in colour to a darker tone could be observed. At a temperature of 250 °C the test item was completely molten and turned black. The test was terminated at a maximum temperature of 260 °C. After the measurement a black residue remained in the capillary.
According to the observations during the test in the capillary method, the effects in the DSC measurements with open crucibles can be assigned to the melting of the test item accompanied by its decomposition in the temperature range of 240 °C to 250 °C.
Applicant's summary and conclusion
- Conclusions:
- The test item 5-Amino-2-nitrobenzoic acid (CAS no. 13280-60-9) has a melting point of 249.5 °C at atmospheric pressure (1004.3 hPa) accompanied by its decomposition starting at a temperature of approx. 250 °C as determined by differential scanning calorimetry and capillary method according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).
- Executive summary:
The test item 5-Amino-2-nitrobenzoic acid (CAS no. 13280-60-9) has a melting point of 249.5 °C at atmospheric pressure (1004.3 hPa) accompanied by its decomposition starting at a temperature of approx. 250 °C as determined by differential scanning calorimetry and capillary method according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).
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