Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 421-090-1 | CAS number: 131298-44-7 Isodecyl benzoate
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10/18/2006 - 02/13/2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP conducted study conducted according to OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class (ATC) Method)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class (ATC) Method)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 421-090-1
- EC Name:
- -
- Cas Number:
- 131298-44-7
- Molecular formula:
- C17H26O2
- IUPAC Name:
- undecyl benzoate
- Reference substance name:
- Benzoic acid, C9-11, C10-rich branched alkyl esters
- IUPAC Name:
- Benzoic acid, C9-11, C10-rich branched alkyl esters
- Reference substance name:
- Isodecyl benzoate
- IUPAC Name:
- Isodecyl benzoate
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Upon receipt, Sprague-Dawley Derived Crl:CD (SD) IGS BR rats were randomly housed individually in hanging stainless steel wire mesh cages. Following acclimation to laboratory conditions (1 week) and pre-test physical examinations, 10 rats (5 males/5 females)were assigned to the study via computer generated random numbers. Certified Rodent Diet 5002 Laboratory Chow (PMI Nutrition Int.) and tap water were made available ad libitum except when withheld during the 4 hour exposure. Fresh feed was presented weekly. A 12-hour light/dark cycle was provided. Daily average temperature range was 19-21degrees C and Relative Humidity ranged from 25-54%. Body weights at time of exposure averaged for males 273 g (267-283 g range) and for females was 225 g (219-234 g range). During exposure the animals were individually housed in polycarbonate tubes attached to a cast aluminum and alloy 40-Liter nose-only exposure chamber. The chamber environment was monitored for temperature, relative humidity (RH) and airflow rate every half-hour during exposure. Temperature was 20ºC and RH ranged within 46 – 54%.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Exposure of the test animals was conducted with a 40-liter nose-only cast aluminum and alloy chamber. Animals were individually housed in polycarbonate tubes attached to the chamber in manifold fashion. The chamber was operated in a dynamic mode with total airflow through the chamber of 22 liters per minute as measured by a calibrated flowmeter. Test material was used as received and was generated as respirable aerosol in the breathing zone of the animals. Pre-study trials were performed to evaluate the optimal set of conditions and equipment to generate a stable atmosphere at the targeted exposure level. The chamber size and airflow rate were considered adequate to maintain an oxygen level of at least 19%. Thechamber was exhausted using a flowmeter with a built in metering valve and backpressure guage, via plastic tubing. The exhaust was filtered throuigh a series of filter pots.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Gravimetrically each hour of exposure; Particle size distribution measurements resulte in an average mass median aerodynamic diameter of 2.41 µm with an average geometric standard deviation of 2.12 µm.
- Duration of exposure:
- ca. 4 h
- Concentrations:
- Average gravimetric exposure concentration of 5.5 mg/L (milligrams of test substance/Liter of air) with a range of 5.2 – 5.7 mg/L. A total of 124.1 grams of test substance was used during the exposure, resulting in a nominal concentration of 23 mg/L. Highly respirable particle size distribution measurements were an average mass median aerodynamic diameter of 2.41 µm with an average geometric standard deviation of 2.12 and 12% of particles ≤ 1.0 µm, 75% of particles ≤ 4.0 µm and 97% of particles ≤ 10 µm.
- No. of animals per sex per dose:
- 5 animals per sex, per dose.
- Control animals:
- no
- Details on study design:
- Isodecyl benzoate was administered as a liquid aerosol to one group of Sprague-DawleyCD rats (5/sex) at a target concentration of 5.0 mg/L via nose-only exposure. The exposure levels were determined gravimetrically during each hour of exposure as were particle size distribution. During the exposure, animals were observed for gross signs of toxicological and pharmacological effects every 15 minutes during the first hour of exposure and hourly through the duration of exposure. Detailed observations were performed on all animals just prior to exposure, immediately upon removal from the exposure chamber, hourly for two hours post- exposure, and once daily thereafter. Body weight measurements were obtained just prior to exposure and weekly thereafter. After a 14-day post-exposure observation period, all animals were sacrificed. Gross postmortem examinations were performed on all animals. The external surface, as well as the thoracic, abdominal and cranial cavities and their organs and tissues were subject to gross examination.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.5 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: Average gravimetric exposure concentration was 5.5 mg/L. Range was 5.2 to 5.7mg/L air.
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 5.5 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: Average gravimetric exposure concentration was 5.5 mg/L. Range was 5.2 to 5.7mg/L air.
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- > 5.5 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: Average gravimetric exposure concentration was 5.5 mg/L. Range was 5.2 to 5.7mg/L air.
- Mortality:
- There were no treatment-related deaths in the study.
- Clinical signs:
- other: Labored breathing was noted in 2 animals during the 4th hour of the exposure period. All other animals were unremarkable for test-substance effect during exposure and during the 14-day observation period.
- Body weight:
- Animals were all weighed just prior to exposure, on day 8 and day 15. All animals gained weight. Mean body weight change from day 1 for males was 46 g (9.4 g S.D.) on day 8; and, 97 g (12.2 g S.D.) on day 15. Mean body weight change from day 1 for females was 14 g (9.1 g S.D.) on day 8; and, 30 g (12.4 g S.D.) on day 15.
- Gross pathology:
- There were no treatment-related findings in gross pathological evaluations.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: other:
- Conclusions:
- The acute inhalation LC50 in rats is > 5.5 mg/L.
- Executive summary:
Isodecyl benzoate was administered as a liquid aerosol to one group of Sprague-Dawley CD rats (5/sex) at 5.5 mg/L via nose only exposure. The study was conducted according to OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class (ATC) Method).
The exposure levels were determined gravimetrically (5.5 mg/L mean gravimetric exposure concentration) during each hour of exposure as were particle size distributions (particle size distribution measurements resulted in an average mass median aerodynamic diameter of 2.41 µm with an average geometric standard deviation of 2.12). During the exposure, animals were observed for gross signs of toxicological and pharmacological effects every 15 minutes during the first hour of exposure and hourly through the duration of exposure. Detailed observations were performed on all animals just prior to exposure, immediately upon removal from the exposure chamber, hourly for two hours post-exposure, and once daily thereafter. Body weight measurements were obtained just prior to exposure and weekly thereafter. After a 14-day post-exposure observation period, all animals were sacrificed. Gross postmortem examinations were performed on all animals. The external surface, as well as the thoracic, abdominal and cranial cavities and their organs and tissues were subject to gross examination.
There were no treatment-related deaths in the study. Labored breathing was noted in 2 animals during the 4th hour of the exposure period. All other animals were unremarkable for test-substance effect during exposure and during the 14-day observation period. Animals were all weighed just prior to exposure, on day 8 and day 15. All animals gained weight. Mean body weight change from day 1 for males was 46 g (9.4 g S.D.) on day 8; and, 97 g (12.2 g S.D.) on day 15. Mean body weight change from day 1 for females was 14 g (9.1 g S.D.) on day 8; and, 30 g (12.4 g S.D.) on day 15. There were no treatment-related findings in gross pathological evaluations.
In conclusion, Isodecyl benzoate was practically non-toxic by inhalation to rats by nose-only inhalation exposure with a 4 -hour LC 50 greated than 5.5 mg/L (mean gravimetric exposure concentration) for males and females.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.