4-chloro-7H-pyrrolo[2,3-d]pyrimidine

Guidance on Safe Use

First-aid measures

Inhalation: Move to fresh air. Call a physician if symptoms develop or persist. For breathing difficulties, oxygen may be necessary.

Skin contact: Remove contaminated clothing. Wash off with soap and plenty of water. If skin irritation or rash occurs: Get medical advice/attention. Wash contaminated clothing before reuse.

Eye contact: Do not rub eyes. Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

Ingestion: Rinse mouth. Call a physician or poison control centre immediately. Only induce vomiting at the instruction of medical personnel. Never give anything by mouth to an unconsious person.

Fire-fighting measures

Suitable extinguishing media:

Water fog. Foam. Dry chemical powder. Carbon dioxide (CO2). Apply extinguishing media

carefully to avoid creating airborne dust. Avoid high pressure media which could cause the

formation of a potentially explosible dust-air mixture.

Unsuitable extinguishing media:

Do not use water jet as an extinguisher, as this will spread the fire.

Special hazards arising from the substance or mixture:

High concentration of airborne dust may form explosive mixture with air. During fire, gases

hazardous to health may be formed.

Special protective equipment for firefighters: Self-contained breathing apparatus and full protective clothing must be worn in case of fire.

Special fire fighting procedures: In case of fire and/or explosion do not breathe fumes. Move containers from fire area if you can do so without risk.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

For non-emergency personnel:

Keep unnecessary personnel away. Local authorities should be advised if significant spillages

cannot be contained.

For emergency responders:

Wear appropriate protective equipment and clothing during clean-up. Keep unnecessary personnel

away. Keep people away from and upwind of spill/leak. Ensure adequate ventilation. Avoid

inhalation of dust from the spilled material. Ventilate the contaminated area. Avoid contact with

eyes, skin, and clothing. Do not touch damaged containers or spilled material unless wearing

appropriate protective clothing.

Environmental precautions: Avoid discharge into drains, water courses or onto the ground.

Methods and material for containment and cleaning up:

Ensure adequate ventilation. Eliminate all ignition sources (no smoking, flares, sparks, or flames in

immediate area). Take precautionary measures against static discharge. Avoid the generation of

dusts during clean-up. Avoid release to the environment.

Large Spills: Stop the flow of material, if this is without risk. Absorb in vermiculite, dry sand or earth

and place into containers. Clean surface thoroughly to remove residual contamination.

Small Spills: Wipe up with absorbent material (e.g. cloth, fleece). Clean surface thoroughly to

remove residual contamination.

Never return spills to original containers for re-use.

Handling and storage

Precautions for safe handling:

Minimise dust generation and accumulation. Routine housekeeping should be instituted to ensure

that dusts do not accumulate on surfaces. Dry powders can build static electricity charges when

subjected to the friction of transfer and mixing operations. Provide adequate precautions, such as

electrical grounding and bonding, or inert atmospheres. Do not handle, store or open near an open

flame, sources of heat or sources of ignition. Protect material from direct sunlight. Avoid breathing

dust. Provide appropriate exhaust ventilation at places where dust is formed. Wear personal protective equipment. Avoid contact with eyes, skin, and clothing. Do not taste or swallow.

Observe good industrial hygiene practices. When using, do not eat, drink or smoke. Wash thoroughly after handling. Wash contaminated clothing before reuse. Avoid release to the environment.

Conditions for safe storage, including any incompatibilities:

Keep containers tightly closed in a dry, cool and well-ventilated place. Do not store in direct

sunlight. Keep away from heat, sparks and open flame. Prevent electrostatic charge build-up by

using common bonding and grounding techniques.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

Not regulated as dangerous goods.

Shipping

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

Not regulated as dangerous goods.

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

Not regulated as dangerous goods.

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

Not regulated as dangerous goods.

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Appropriate engineering controls:

Provide adequate general and local exhaust ventilation. Keep air contamination levels below the

exposure limits or within the OEB range. Use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits or within the OEB range.

Individual protection measures, such as personal protective equipment

General information: Use personal protective equipment as required. Personal protection equipment should be chosen according to the CEN standards and in discussion with the supplier of the personal protective equipment.

Eye/face protection: Wear safety goggles as minimum protection (additionally, face shield recommended for open handling).

Skin protection: Wear appropriate chemical resistant gloves. Nitrile gloves are recommended.

Wear appropriate chemical resistant clothing. Impervious protective clothing is recommended if

skin contact with drug product is possible and for bulk processing operations.

Respiratory protection:

In case of insufficient ventilation, wear suitable respiratory equipment. Respiratory protection

should be provided in instances where exposure to dust, mists, aerosols or vapors are likely. If

airborne exposures are within or exceed the Occupational Exposure Band (OEB) range, wear an

appropriate respirator with a protection factor sufficient to control exposures to the bottom of the

OEB range. Chemical respirator with organic vapour cartridge, full facepiece, dust and mist filter.

Use a positive-pressure air-supplied respirator if there is any potential for an uncontrolled release,

exposure levels are not known, or any other circumstances where air-purifying respirators may not

provide adequate protection.

Stability and reactivity

Reactivity: The product is stable and non-reactive under normal conditions of use, storage and transport.

Chemical stability: Material is stable under normal conditions.

Possibility of hazardous reactions: No dangerous reaction known under conditions of normal use.

Conditions to avoid: Contact with incompatible materials. Minimise dust generation and accumulation. Keep away from heat, sparks and open flame.

Incompatible materials: Strong oxidising agents.

Hazardous decomposition products: Irritating and/or toxic fumes and gases may be emitted upon the product's decomposition. Nitrogen oxides (NOx). Carbon oxides. May include hydrogen chloride.

Disposal considerations

Residual waste:

Dispose of in accordance with local regulations. Empty containers or liners may retain some

product residues. This material and its container must be disposed of in a safe manner.

Contaminated packaging:

Since emptied containers may retain product residue, follow label warnings even after container is

emptied.

EU waste code: The Waste code should be assigned in discussion between the user, the producer and the waste disposal company.

Disposal methods/information:

Avoid release to the environment. Do not allow this material to drain into sewers/water supplies.

Do not discharge into drains, water courses or onto the ground. Considering the relevant known

environmental and human health hazards of the material, review and implement appropriate

technical and procedural waste water and waste disposal measures to prevent occupational

exposure and environmental release. It is recommended that waste minimization be practiced.

The best available technology should be utilized to prevent environmental releases. This may

include destructive techniques for waste and wastewater. Dispose of contents/container in

accordance with local/regional/national/international regulations.

Special precautions: Dispose in accordance with all applicable regulations.