Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 256-275-4 | CAS number: 46728-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- The full test method is described in:
Ewell, WS, Gorsuch, JW, Kringle, RO, Robillard, KA, Spiegel, RC (1986). Simultaneous evaluation of the acute effects of chemicals on seven aquatic species. Environ. Toxicol. Chem. 5:831-840. - GLP compliance:
- no
Test material
- Reference substance name:
- Sodium hydrogen-5-sulphoisophthalate
- EC Number:
- 228-845-2
- EC Name:
- Sodium hydrogen-5-sulphoisophthalate
- Cas Number:
- 6362-79-4
- Molecular formula:
- C8H6O7S.Na
- IUPAC Name:
- Sodium 3,5-dicarboxybenzenesulfonate
- Reference substance name:
- 288-845-2
- IUPAC Name:
- 288-845-2
- Reference substance name:
- Sodium-3,5-dicarboxybenzenesulfonate
- IUPAC Name:
- Sodium-3,5-dicarboxybenzenesulfonate
- Reference substance name:
- 5-(Sodiosulfo)isophthalic acid
- IUPAC Name:
- 5-(Sodiosulfo)isophthalic acid
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material: 5-(Sodiosulfo)isophthalic Acid
- Appearance/Physical form: powder
- Formula Weight: 268 g/mol
- Molecular Formula: C8H6O7S-1Na
- Purity: >92% (assay)
- Impurities: sodium sulfate,= 2.0%; water,= 5.0%; NaCl,= 500 ppm; sulfuric acid,= 0.2%
- Lot/batch No.: ARK BA103-81; X-17007-226
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Chemicals known to be soluble at 100mg/l were added directly to dilution water.
Test organisms
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- All test organisms were acclimated to the control diluent water in breeding/rearing tanks. Food was withheld for the 24 h preceding the start of testing. Ten juveniles, as uniform in size as possible, were collected from the breeding colonies. Biological loading was kept below 0.5 g wet weight per liter of test solution. Fathead minnows typically weighed 0.2 to0.5 g.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- Not applicable
Test conditions
- Test temperature:
- 20 ± 1 °C
- pH:
- 6.5 to 8.5
- Dissolved oxygen:
- Maintained at 40% or greater of the starting level. If levels fell below this, the test was repeated with 0.05 l/min of aeration.
- Nominal and measured concentrations:
- Nominal concentrations were employed. The material is completely water soluble. In addition, based on analytical measurements, stable 100 mg/l concentrations of the test material were maintained in an algal toxicity study. Thus, the use of nominal concentrations is justified.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Seamless glass 30.5 cm cuboidal Pyrex jars of 20 l capacity
- Type: open
- Aeration: if required
- No. of organisms per vessel: 10 of each species
- No. of vessels per concentration: 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.5 g wet weight/l (fish)
TEST MEDIUM / WATER PARAMETERS (Typical values)
- Source/preparation of dilution water: Industrial service water from Lake Ontario, Rochester, NY (USA). Filtered through activated carbon and chlorinated.
- Total organic carbon: 1.8 mg/l
- Metals: Measured routinely and all within acceptable levels.
- Chlorine: 6.6 µg/l (residual)
- Total dissolved solids: 180 mg/l
- Total hardness (CaCO3): 130 mg/l
- pH: 7.4
Photoperiod: 16 h light
The air-water interface of each tank received approximately 50 ft-c of cool-white fluorescent light.
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- A nominal 100 mg/l solution of the test material caused a 10% mortality of fish.
- Results with reference substance (positive control):
- See the publication by Ewell et al. (1986) for reference values.
- Reported statistics and error estimates:
- LC50 values were estimated using a computer program of Stephan (Methods for calculating an LC50: Aquatic toxicology and hazard evaluation. In F.L. Mayer and J.L. Hameling, eds., STP 634. American Society for Testing and Materials, Philadelphis, PA, pp 65-84).
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Biological observations were made daily. Survival, condition and behavioral information were recorded. Dead organisms were removed when observed. Total exposure times were 96 h.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The acute aquatic LC50 value for the test material in fish was > 100 mg/l.
- Executive summary:
Exposure for 96 h of 10 fish (Pimephales promelus) resulted in a single mortality. The LC50 value was > 100 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.