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EC number: 947-603-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- data is from experimental report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: method described in the 'Code of Federal Regulations', Title 15, Section 1500.41
- Principles of method if other than guideline:
- To predict the potential for inflammatory or corrosive activity in single, occluded, primary contact of the test chemical with the skin of the rabbit
- GLP compliance:
- not specified
Test material
- Reference substance name:
- octasodium 2,2'-[(2,2'-disulphonato[1,1'-biphenyl]-4,4'-diyl)bis[imino(6-chloro-1,3,5-triazine-4,2-diyl)imino(1-hydroxy-3-sulphonatonaphthalene-6,2-diyl)azo]]bisnaphthalene-1,5-disulphonate
- Cas Number:
- 68110-30-5
- Molecular formula:
- C58H30Cl2N14Na8O26S8
- IUPAC Name:
- octasodium 2,2'-[(2,2'-disulphonato[1,1'-biphenyl]-4,4'-diyl)bis[imino(6-chloro-1,3,5-triazine-4,2-diyl)imino(1-hydroxy-3-sulphonatonaphthalene-6,2-diyl)azo]]bisnaphthalene-1,5-disulphonate
- Test material form:
- solid
- Details on test material:
- Name of the test chemical: Octasodium 2,2'-[(2,2'-disulphonato[1,1'-biphenyl]-4,4'-diyl)bis[imino(6-chloro-1,3,5-triazine-4,2-diyl)imino (1-hydroxy-3-sulphonatonaphthalene-6,2-diyl)azo]]bisnaphthalene-1,5-disulphonate
Molecular formula: C58H30Cl2N14Na8O26S8
Molecular weight: 1850.3 g/mol
Smiles Notation: [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].c1(c(cc(cc1)Nc1nc(nc(n1)Cl)Nc1cc2cc(c(c(c2cc1)O)\N=N\c1c(c2cccc(c2cc1)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])c1c(cc(cc1)Nc1nc(nc(n1)Cl)Nc1cc2cc(c(c(c2cc1)O)\N=N\c1c(c2cccc(c2cc1)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-]
InChI: 1S/C58H38Cl2N14O26S8.8Na/c59-53-65-55(61-27-7-11-31-25(19-27)21-45(105(89,90)91)47(49(31)75)73-71-39-17-15-35-37(51(39)107(95,96)97)3-1-5-41(35)101(77,78)79)69-57(67-53)63-29-9-13-33(43(23-29)103(83,84)85)34-14-10-30(24-44(34)104(86,87)88)64-58-68-54(60)66-56(70-58)62-28-8-12-32-26(20-28)22-46(106(92,93)94)48(50(32)76)74-72-40-18-16-36-38(52(40)108(98,99)100)4-2-6-42(36)102(80,81)82;;;;;;;;/h1-24,75-76H,(H,77,78,79)(H,80,81,82)(H,83,84,85)(H,86,87,88)(H,89,90,91)(H,92,93,94)(H,95,96,97)(H,98,99,100)(H2,61,63,65,67,69)(H2,62,64,66,68,70);;;;;;;;/q;8*+1/p-8/b73-71+,74-72+;;;;;;;;
Substance Type: Organic
Physical State: Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Sex: male
- Weight at study initiation: 2.5 - 3.5 kg bodyweight
- Housing:were housed individually in suspended galvanized and stainless steel cages (from Cope and Cope Ltd.), measuring 0.6 x 0.6 x 0.4 m high and fitted with mesh floors and automatic watering
- Diet (e.g. ad libitum): complete pelleted rabbit diet; Diet RAG modified, from Labsure Animal Foods, Poole, Dorset; ad libitum
- Water (e.g. ad libitum): water; ad libitum
- Acclimation period:All rabbits were held for a minimum period of seven days before entering the study.
- Identification: Each animal was weighed and allocated by random selection to the appropriate test group, in which it was identified by numbered ear-tag.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Room temperature was controlled within the range 15 0 ± 2 0 C
- Photoperiod (hrs dark / hrs light):lighting was restricted to 14 hours in each period of 24 hours
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 g moistened with water
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24,48 and 72 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: back
- % coverage: a square patch of surgical gauze measuring 2.5 cm x 2.5 cm
- Type of wrap if used: The entire trunk of the animal is then wrapped with an impervious material such as rubber or PVC (after ensuring that the test substance does not react chemically with the rubber or PVC)
OBSERVATION TIME POINTS
(indicate if minutes, hours or days): 24, 48 and 72 hours
SCORING SYSTEM:
- Method of calculation: Draize method
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No responses were detected and a Primary Irritation Index of zero was obtained
Any other information on results incl. tables
Scoring of irritance responses elicited by single dermal occlusive applications to the dorsum of rabbits
Animal number, sex |
Type of response |
Score at 24 hours |
Score at 72 hours |
Overall score |
Score at day 7 |
|||
Intact skin |
Abraded skin |
Intact skin |
Abraded skin |
Intact skin |
Abraded skin |
|||
323, Male |
Erythema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
edema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
325, male |
Erythema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
edema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
326, male |
Erythema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
edema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
328, male |
Erythema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
edema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
328, male |
Erythema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
edema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
329, male |
Erythema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
edema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
330, male |
Erythema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
edema |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Primary Irritation Score = 0
Overall Irritation Score = 0
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- The test chemical was assessed for primary irritation to the skin of rabbits according to the Ecological and Toxicological Association of Dyestuffs Manufacturers (ETAD) test based upon the method described in the 'Code of Federal Regulations', Title 15, Section 1500.41.
Under the test conditions employed, the test chemical produced a Primary Irritation Index within the range 0.0 - 0.5 and was thus classified 'non-irritant' to skin. - Executive summary:
A study was conducted according to the method described in the 'Code of Federal Regulations', Title 15, Section 1500.41 to predict the potential for inflammatory or corrosive activity in single, occluded, primary contact of the test chemical with the skin of the rabbit. 6 albino male New Zealand White rabbits were used for the study. The rabbits were fed standard pelleted rabbit diet and water, ad libitum and housed in metal cages throughout the study. Before intended application, both sides of the back were clipped as close to the skin as possible using electric clippers (chemical depilatories were not used). Two to three hours later, abrasions were made to the upper third of one side of the back (flank area behind the ribs). The abrasions were made by using the back of the point of a scalpel blade to scratch a 5 x 5 lattice in an area measuring 2.5cm2 , such that only the stratum corneum was penetrated and bleeding did not occur. 0.5 g of powder were prepared as a paste by addition of a minimal volume of water.One application is made to the skin area previously abraded and one application is made to the intact skin in the corresponding position on the other side of the back. The entire trunk of the animal is then wrapped with an impervious material such as rubber or PVC (after ensuring that the test substance does not react chemically with the rubber or PVC) for the 24-hour period of exposure. The animal was not immobilised but the patches are held in place using bandages or elasticated stockingette. After the 24-hour exposure, the patches are removed and the reactions evaluated without washing the application site The dermal reactions were observed and scored at 24,48 and 72 hours according to the method of Draize. No responses were detected and a Primary Irritation Index of zero was obtained.It was thus classified under the category "Not Classified".
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