1-chloro-2-nitrobenzene

Endpoint summary

Description of key information

Single studies were performed to examine the allergic potential of o-chloronitrobenzene. The test methods of these studies are not consistent with any guideline and are incompletely documented. In all of these studies, sensitizing effects on skin or respiratory system were mentioned. Due to the limited information available it cannot be concluded whether or not the chemical has a sensitizing activity.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion

Additional information:

Skin sensitization potency was examined in tests with 10 guinea pigs using test methods which are no longer in use and which are incompletely documented (Rusakov 1973): In a modified Draize test induction was performed with a 1 % acetone-solution of the compound on the shaved back for 5 consecutive days. At day 7 a challenge was performed with the same solution. As there was no skin reaction observed, a modified Freunds complete adjuvant test was performed: the same guinea pigs were treated with a 10 % solution of 1-chloro-2-nitrobenzene at day 22: 0.2 mL Freunds Adjuvans together with 0.5 mg 1-chloro-2-nitrobenzene/kg bw was injected into the hind paw. 6 days later one drop of a 10 % solution of 1-chloro-2-nitrobenzene was applied on the shaved untreated skin as challenge. The author reported that 50 % of the treated guinea pigs showed a positive reaction.

Respiratory sensitisation

Endpoint conclusion

Additional information:

Rats exposed via inhalation to 0.008 mg/m³for 5 months showed also positive reactions (see above; Rusakov et al. 1973).

Justification for classification or non-classification

Due to the poor quality of the data, a conclusion regarding classification for skin or respiratory sensitising properties cannot be made.