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Diss Factsheets
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EC number: 945-920-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 13, 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study meets the EC Standards (conducted equivalent to OECD 401). Non GLP. Deviations: no details on test material, limited details on test animals and environmental conditions. However, dose, number of animals and observation period and considering mortality observed, the result is considered reliable with restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 963
- Report date:
- 1963
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- no details on test material, limited details on test animals and environmental conditions.
- GLP compliance:
- no
- Remarks:
- not present at the time of performance.
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 1-methyl-4-(4-methylpentyl)cyclohex-3-ene-1-carbaldehyde
- EC Number:
- 266-314-7
- EC Name:
- 1-methyl-4-(4-methylpentyl)cyclohex-3-ene-1-carbaldehyde
- Cas Number:
- 66327-54-6
- Molecular formula:
- C14H24O
- IUPAC Name:
- 1-methyl-4-(4-methylpentyl)cyclohex-3-ene-1-carbaldehyde
- Reference substance name:
- 1-methyl-3-(4-methylpentyl)-3-Cyclohexene-1-carboxaldehyde
- Cas Number:
- 693252-50-5
- Molecular formula:
- C14H24O
- IUPAC Name:
- 1-methyl-3-(4-methylpentyl)-3-Cyclohexene-1-carboxaldehyde
- Reference substance name:
- Cyclohexanecarboxaldehyde, 1-methyl-4-(4-methylpentyl)-, trans-
- Cas Number:
- 76169-46-5
- Molecular formula:
- C14H26O
- IUPAC Name:
- Cyclohexanecarboxaldehyde, 1-methyl-4-(4-methylpentyl)-, trans-
- Reference substance name:
- Cyclohexanecarboxaldehyde, 1-methyl-4-(4-methylpentyl)-, cis-
- Cas Number:
- 76169-45-4
- Molecular formula:
- C14H26O
- IUPAC Name:
- Cyclohexanecarboxaldehyde, 1-methyl-4-(4-methylpentyl)-, cis-
- Reference substance name:
- 1-methyl-4-(4-methylpentylidene)cyclohexanecarbaldehyde
- Molecular formula:
- C14H24O
- IUPAC Name:
- 1-methyl-4-(4-methylpentylidene)cyclohexanecarbaldehyde
- Reference substance name:
- 1-methyl-4-(4-methyl-3-pentenyl)cyclohex-3-ene-1-carbaldehyde
- EC Number:
- 257-942-2
- EC Name:
- 1-methyl-4-(4-methyl-3-pentenyl)cyclohex-3-ene-1-carbaldehyde
- Cas Number:
- 52475-86-2
- Molecular formula:
- C14H22O
- IUPAC Name:
- 1-Methyl-4-(4-methylpent-3-en-1-yl)cyclohex-3-ene-1-carbaldehyde
- Reference substance name:
- 1-methyl-3-(4-methylpentylidene)cyclohexanecarbaldehyde
- Molecular formula:
- C12H24O
- IUPAC Name:
- 1-methyl-3-(4-methylpentylidene)cyclohexanecarbaldehyde
Constituent 1
Constituent 2
impurity 1
impurity 2
impurity 3
impurity 4
impurity 5
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Compound A - 7155 (1-Formyl1-Methyl-4-(4methyl-dentan-1-yl)-Cyclohexane)
- Description: colorless liquid
Please note that although the substance is stated as a mono-constituent substance 21-Formyl1-Methyl-4-(4methyl-dentan-1-yl)-Cyclohexane in the report, recent analytical data had been determined the substance to be a multi-constituent (Reaction mass of 1-methyl-3-(4-methylpentyl)-3-cyclohexene-1-carboxaldehyde and 1-methyl-4-(4-methylpentyl)-3-cyclohexene-1-carboxaldehyde). As the chemical manufacturing process has not changed since the report was written, the recent analytical information is relevant to the batch which was tested.
Test animals
- Species:
- rat
- Strain:
- other: Holtzman
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 100 to 125 g
- Housing: in raised wire mesh cages
- Diet: regular diet of Fox Blox
Administration / exposure
- Route of administration:
- other: intragastrically (gavage)
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- GAVAGE METHOD: rigid stomach tube, single dose.
MAXIMUM DOSE VOLUME APPLIED: 8.0 mL/kg) body weight - Doses:
- 1.0, 1.3, 6.0, 6.2, 6.5, 7.0, 7.5 and 8.0 mL/kg body weight. We assume dose 1.0 and 1.3 should read 10 and 13 mL/kg considering the results.
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Clinical signs for observation: loss in body weight, convulsions, ataxia, emesis and or death
- Necropsy of survivors performed: no - Statistics:
- The method of Litchfield, V.T. and Wilcoxon, F., Journal of Pharmacology and Experimental Therapeutics, Vol/ 96, p.99, 1949 was used in calculating the oral LD50.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 7.73 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 7 - 8.5
- Mortality:
- 6.0 mL/kg: 0/10
6.2 mL/kg: 1/10
6.5 mL/kg: 3/10
7.0 mL/kg: 3/10
7.5 mL/kg: 4/10
8.0 mL/kg: 6/10
10 mL/kg: 8/10
13 mL/kg: 10/10 - Clinical signs:
- other: Not reported.
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study with rats, performed equivalent to OECD 401 guidelines, an LD50 of 7.73 mL/kg bw was determined.
- Executive summary:
Compound A - 7155 (1-Formyl1-Methyl-4-(4methyl-dentan-1-yl)-Cyclohexane) was tested in an acute oral toxicity study with rats, performed equivalent to OECD 401 guideline. Deaths occurred starting at the 6.2 mL/kg dose level.
Based on the results, an LD50 of 7.73 mL/kg bodyweight was determined.
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