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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

C4 F-isonitrile is hydrolytically active when brought into contact with water. Aquatic toxicity testing was done on the hydrolysis product perfluoroisopropylamide. All key aquatic toxicity studies were performed in accordance with internationally-accepted test guidelines and are Good Laboratory Practice (GLP) compliant. As such, these results are considered reliable without restrictions. The results are suitable for purposes of Risk Assessment, Classification & Labeling, and PBT Analysis. Two non-GLP range finding studies were performed for algae and invertebrates. All aquatic toxicity results are reproduced in the table below.

Table 1. Test Results

Species

Endpoint

Concentration (mg/L)

Result Parameter

Reliability (Klimisch)

Fish (Gobiocypris rarus)

96-hour LC50

>127 (equivalent to 100 mg/L parent)

mortality

1

Invertebrate (Daphnia magna)

Invertebrate (Daphnia magna)

48-hour EC50

48-hour EC50 RF*

>100

>100

immobilization

mortality

1

2

Algae (Pseudokirchneriella subcapitata) 

Algae (Pseudokirchneriella subcapitata)

72-hour EC50
72-hour NOEC

 

72-hour EC50 RF*
72-hour NOEC RF*

>100
10

>100

100

growth rate

cell number

1

2
 Activated sludge  3 -hour EC50  >1000  respiration 1

RF* indicates the study was a non-GLP method, range finding test