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Diss Factsheets
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EC number: 209-566-5 | CAS number: 585-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
- Reference Type:
- other: Published secondary source
- Title:
- Lactitol
- Author:
- WHO/FAO
- Year:
- 1 983
- Bibliographic source:
- WHO/FAO: Expert Committee on Food Additives Summary of Toxicological Data of Certain Food Additives Series 18 (http://www.inchem.org/documents/jecfa/jecmono/v18je10.htm)
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- exposure was for 24 hours
- Qualifier:
- according to guideline
- Guideline:
- other: ISO/DIS 634, Draft International standard
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-O-β-D-galactopyranosyl-D-glucitol
- EC Number:
- 209-566-5
- EC Name:
- 4-O-β-D-galactopyranosyl-D-glucitol
- Cas Number:
- 585-86-4
- Molecular formula:
- C12H24O11
- IUPAC Name:
- 4-O-beta-D-galactopyranosyl-D-glucitol
Constituent 1
- Specific details on test material used for the study:
- Test material:
- lactitoldihydrate (provided by CCA).
- tests carried out with a sample of the homogenized lot sent to CIVO-TNO.
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Test organisms:
- Animals were cultured at TNO in dilution water.
- Daphnia magna had a generation time of about 7 days and the average life time about 6 weeks. A nimals less than 24 hrs old were used for the tests.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 24 h
Test conditions
- Hardness:
- 250 mg/L as CaCO3
- Test temperature:
- Not specified
- pH:
- 8.2 ± 0.2
- Nominal and measured concentrations:
- 10000 mg/L
- Details on test conditions:
- Since the test substance was not thought to be toxic, only one concentration (10000 mg/L) in dilution water was tested and compared with untreated dilution water.
Results and discussion
Effect concentrations
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 000 mg/L
- Details on results:
- The oxygen concentration at the end of the test was 8.5 mg/L in the untreated dilution water and 7.9 mg/L in the dilution water containing 10000 mg/L test substance. The pH in both solutions was 7.8 ± 0.1. No immobilization of any Daphnia occurred during the 24-hr exposure period in the untreated dilution water or in the dilution water containing 10000 mg/L test substance.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- LC50 (Daphnia magna): > 10000 mg/L
- Executive summary:
The toxicity to Daphnia magna was examined in accordance with OECD Guideline 202. Lactitoldihydrate at a nominal concentration of 10000 mg/L did not show any acute toxicity for Daphnia magna. The LC50 for Daphnia magna was determined to be > 10000 mg/L
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