[No public or meaningful name is available]

Surface tension

Administrative data

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11 September 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2019

Report date:

2019

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Version / remarks:

1995

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Version / remarks:

Regulation EC No. 440/2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

ring method

Test material

Test material information

Constituent 1

Reference substance name:

3-(aminocarbonyl)-1-ß-D-ribofuranosyl-pyridinium bromide

Cas Number:

78687-39-5

Molecular formula:

C11H15BrN2O5

IUPAC Name:

3-(aminocarbonyl)-1-ß-D-ribofuranosyl-pyridinium bromide

impurity 1

Reference substance name:

Nicotinamide

EC Number:

202-713-4

EC Name:

Nicotinamide

Cas Number:

98-92-0

Molecular formula:

C6H6N2O

IUPAC Name:

nicotinamide

impurity 2

Reference substance name:

Methanol

EC Number:

200-659-6

EC Name:

Methanol

Cas Number:

67-56-1

Molecular formula:

CH4O

IUPAC Name:

methanol

impurity 3

Reference substance name:

Ethyl acetate

EC Number:

205-500-4

EC Name:

Ethyl acetate

Cas Number:

141-78-6

Molecular formula:

C4H8O2

IUPAC Name:

ethyl acetate

impurity 4

Reference substance name:

Water

EC Number:

231-791-2

EC Name:

Water

Cas Number:

7732-18-5

Molecular formula:

H2O

IUPAC Name:

Oxidane

impurity 5

Reference substance name:

inorganic salts by sulphated ash

IUPAC Name:

inorganic salts by sulphated ash

impurity 6

Reference substance name:

Bromic acid

EC Number:

232-158-3

EC Name:

Bromic acid

Cas Number:

7789-31-3

Molecular formula:

BrHO3

IUPAC Name:

bromic acid

impurity 7

Reference substance name:

Unknown impurities.

Molecular formula:

Not available as unknown impurities.

IUPAC Name:

Unknown impurities.

Test material form:

solid

Details on test material:

Batch / Lot No. 1000146/01

Specific details on test material used for the study:

Batch No.: 1000146/01
Storage Conditions: Freezer (approx. -15 °C)

Results and discussion

Surface tension

Key result

Surface tension:

70.39 mN/m

Temp.:

20 °C

Conc.:

1.001 g/L

Remarks on result:

other: Overall mean of first measurement (6 values measured) and second measurement (6 values measured); The concentration refers to the nominal concentration of the test item

Any other information on results incl. tables

The detailed results of two measurements are summarized in the table below.

Value No.	First measurement; 98 min after preparation of the solution (mN/m)	Second measurement; 124 min after preparation of the solution (mN/m)
1	70.28	70.51
2	70.28	70.51
3	70.28	70.50
4	70.28	70.50
5	70.29	70.50
6	70.29	70.50
Mean value of the individual values	70.28 ± 0.01	70.50 ± <0.01
Total mean value	70.39 ± 0.11

Applicant's summary and conclusion

Conclusions:

According to OECD Test Guideline 115 and Regulation EC No. 440/2008 Part A Method A.5. the surface tension at 20°C of the test item Nicotinamide-beta-D-riboside bromide (CAS no. 78687-39-5) was determined to be 70.39 mN/m. According to Regulation EC No. 440/2008 Part A Method A.5. the test item is not to be regarded as surface active material.

Executive summary:

According to OECD Test Guideline 115 and Regulation EC No. 440/2008 Part A Method A.5. the surface tension at 20 °C of the test item Nicotinamide-beta-D-riboside bromide (CAS  no.78687-39-5) was determined to be 70.39 mN/m. According to Regulation EC No. 440/2008 Part A Method A.5. the test item is not to be regarded as surface active material.