Registration Dossier
Registration Dossier
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EC number: 434-080-7 | CAS number: 208343-47-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish. No acute toxic effects occur within the range of solubility.
Key value for chemical safety assessment
Additional information
A study conducted according to OECD guideline 203 is available (RCC Ltd., 2000d). Zebra fish were used as test organisms and the LC50 after 96 hours of exposure was determined to be > 100 mg/L based on nominal concentrations. However, a water accommodated fraction was prepared and the recovery in the highest tested concentration was only 0.0026 mg/L. The water solubility was determined to be < 0.046 mg/L (which was the LOQ in the water solubility study). Therefore the result of the study is considered as: No toxicity in the range of solubility of the test item.
Additionally, a second semi-static test according to OECD guideline 203 with zebra fish has been conducted (Institute of Ecotoxicology, Gakushuin University, 2000). Due to low water solubility an emulsifier (HCO-20) has been used and the LC50 (96 h) was found to be 24 mg/L (NOEC = 16 mg/L). However, the tested concentrations and also the effect concentrations exceeded by far the water solubility and additionally, the NOEC is well above water solubility. Hence, no toxic effects in the range of water solubility could be observed.
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