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EC number: 214-379-7 | CAS number: 1123-85-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance 2-phenylpropan-1-ol was tested for acute oral toxicity to rats and an LD50 of 2.3 g/kg bw was found. When tested for acute dermal toxicity to rabbits, and LD50 of >5 g/kg bw was found.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The studies were performed in 1974, prior to availability of OECD guidelines and EU-testing methods, but however do follow scientific principles.
Oral toxicity was tested at six different dose levels with 10 rats each, whereas deraml toxicity was only tested at one dose level (5 g/kg bw) as this value already was lower than the LD50 (1 out of 5 animals died). Symptom observed were recorded and reported. - GLP compliance:
- no
- Remarks:
- pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Six doses (5, 3, 2.5, 2, 1 and 0.5 g/kg bw) were applied to 10 animals per dose group.
- No. of animals per sex per dose:
- 10 animals per dose group (5m & 5f)
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 300 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 893 - <= 2 707
- Mortality:
- At 5 g/kg bw all animals died (8 on day 1, 1 on day 2 and 1 on day 4)
At 3 g/kg bw eight animals died on day 1, but none thereafter
At 2.5 g/kg bw five animals died on day 1, but none thereafter
At 2 g/kg bw 3 animals died on day 1 and none thereafter
At 1 g/kg one animal died on day 1 and none thereafter
At 0.5 g/kg bw none of the animals died - Clinical signs:
- other: Ataxia, depression, loss of righting reflex, increased respiration, tremors and twitches were observed symptoms.
- Gross pathology:
- no data
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- not applicable to CLP
- Conclusions:
- The LD50 determined was 2.3 ±0.407 g/kg bw.
- Executive summary:
The substance was assessed for acute oral toxicity to rats, by applying six different doeses (0.5, 1, 2, 2.5, 3 and 5 g/kg bw) to groups of 10 rats each (males and females). Mortality was observed at all dose groups except of 0.5 g/kg bw. The LD50 determined was 2.3 ±0.407 g/kg bw. Symptoms observed were ataxia, depression, loss of righting reflex, increased respiration, tremors and twitches.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 300 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The studies were performed in 1974, prior to availability of OECD guidelines and EU-testing methods, but however do follow scientific principles.
Oral toxicity was tested at six different dose levels with 10 rats each, whereas deraml toxicity was only tested at one dose level (5 g/kg bw) as this value already was lower than the LD50 (1 out of 5 animals died). Symptoms observed were recorded and reported. - GLP compliance:
- no
- Remarks:
- pre-dates GLP guidelines
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- 5 g/kg bw was applied neat to rabbit skin
- Duration of exposure:
- 24 hours exposure
- Doses:
- 5 g/kg bw
- No. of animals per sex per dose:
- 5 animals (males and females)
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One out of 5 animals died on day 1; thereafter during 14 days observation period no further mortality was observed
- Clinical signs:
- other: No skin irritation was seen.
- Gross pathology:
- not reported
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 (dermal, rabbit) was found being > 5000 mg/kg bw.
- Executive summary:
Five rabbits (male and female) were exposed to 5 g/kg bw during 24 hours exposure period and mortality was observed for 14 days. One animal died on day 1, but thereafter no further mortality was observed. Therefore, the LD50 was determined at >5000 mg/kg bw and no further dose groups were exposed. No skin irritation was observed during the study.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
At 5000 mg/kg bw dermal exposure to rabbits only one animal out of five died; thus, the LD50 was determined as >5000 mg/kg bw.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.