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Diss Factsheets
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EC number: 271-766-3 | CAS number: 68607-67-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
No experimental studies regarding toxicokinetics of formaldehyde, reaction products with ethylenediamine are available. Nevertheless available data and information derived from the testing strategy adopted for the chemical permit to evaluate main aspects of the substance toxicokinetics.
Formaldehyde, reaction products with ethylenediamine is expected to be absorbed by oral and inhalation route as, in the acute toxicity studies by these routes, systemic effects have been observed. Although in the inhalation toxicity study a mist of the chemical has been produced by atomization, formaldehyde, reaction products with ethylenediamine is expected to be present in moderate quantities as vapour in the environment, according to the vapour pressure value of 2,176 Pa at 20°C (water: 3,200 Pa at 25°C). Systemic effects were not observed in the dermal acute toxicity study at the dose of 2,000 mg/kg bw, but the chemical produced only local effects linked to slight skin irritation. Results of this study may lead to the conclusion that the chemical is expected to have a low skin absorption. In addition, formaldehyde, reaction products with ethylenediamine is a hydrophilic compound and it is expected to be ionised at the slight acidic pH of the skin (pKa 8.18). Ionised products do not penetrate very much through the skin and, in addition, considering that rat skin is more permeable the human skin, formaldehyde, reaction products with ethylenediamine is expected to have a low percutaneous absorption in humans.
Systemic effects observed in toxicity studies do not permit to make considerations on the distribution of formaldehyde, reaction products with ethylenediamine, however, as no histopathological lesions of the organs, with the exception of kidneys and stomach in the 28-day repeated toxicity study, have been observed, and considering the low calculated logPOWfor the substance, a limited distribution or a low bioaccumulation potential can be expected for formaldehyde, reaction products with ethylenediamine. Low bioaccumulation potential can also be supported by the low predicted BCF (1,41 L/kg ww) of the substance.
As toxicity effects related to formaldehyde, reaction products with ethylenediamine have been observed in kidneys, it can be expected that renal excretion is a probable route of elimination of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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