Registration Dossier
Registration Dossier
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EC number: 272-047-7 | CAS number: 68650-79-3
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Publication with only few information.
Data source
Reference
- Reference Type:
- publication
- Title:
- Cross-reaction pattern of the cationic emulsifier oleamidopropyl dimethylamine.
- Author:
- de Groot AC, Jagtman BA, van der Meeren HL, Bruynzeel DP, Bos JD, den Hengst CW, Weyland JW.
- Year:
- 1 988
- Bibliographic source:
- Contact Dermatitis. 1988 Oct;19(4):284-9.
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
Test material
- Reference substance name:
- Amides, C18-unsatd., N-[3-(dimethylamino)propyl]
- EC Number:
- 800-353-8
- Cas Number:
- 1379524-06-7
- Molecular formula:
- C23H46N2O, C23H44N2O, C23H42N2O C18-unsat DMAPA condensation product is including the substance with 1, 2 and 3 unsaturations in CIS position.
- IUPAC Name:
- Amides, C18-unsatd., N-[3-(dimethylamino)propyl]
- Details on test material:
- Publication
1
Results and discussion
- Results of examinations:
- 13 patients allergic to the cationic emulsifier oleamidopropyl dimethylamine were tested with a series of related amide-amine type surfactants in order to investigate its cross-reaction pattern. With 1 exception, all patients reacted to at least 4 of the test materials. Most reactions were observed to ricinoleamidopropyl dimethylamine lactate and tallowamidopropyl dimethylamine (11 patients, 85%); 9 patients (of 12 tested, 75%) reacted to lauramidopropyl dimethylamine and 6 (46%) to myristamidopropyl dimethylamine. A certain pattern of cross-reactivity was recognised.
Applicant's summary and conclusion
- Executive summary:
13 patients allergic to the cationic emulsifier oleamidopropyl dimethylamine were tested with a series of related amide-amine type surfactants in order to investigate its cross-reaction pattern. With 1 exception, all patients reacted to at least 4 of the test materials. Most reactions were observed to ricinoleamidopropyl dimethylamine lactate and tallowamidopropyl dimethylamine (11 patients, 85%); 9 patients (of 12 tested, 75%) reacted to lauramidopropyl dimethylamine and 6 (46%) to myristamidopropyl dimethylamine. A certain pattern of cross-reactivity was recognised.
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