Registration Dossier
Registration Dossier
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EC number: 403-470-9 | CAS number: - CYANEX (R) EXTRACTANT; CYANEX 923 EXTRACTANT
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- A mixture of: hexyldioctylphosphineoxide; dihexyloctylphosphineoxide; trioctylphosphineoxide
- IUPAC Name:
- A mixture of: hexyldioctylphosphineoxide; dihexyloctylphosphineoxide; trioctylphosphineoxide
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 5 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 0/10
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test materials was evaluated for acute oral toxicity in fixe male and five female Sprague Sawley rats. The test material was administered by gavae to each of ten rats at a level of 5 g/kg bw. All animals survived the 15 day post administration observation period. Based on this result, the acute oral LD50 of the substance is considered to be greater than 5 g/kg bw.
- Executive summary:
The test materials was evaluated for acute oral toxicity in fixe male and five female Sprague Sawley rats. The test material was administered by gavae to each of ten rats at a level of 5 g/kg bw. All animals survived the 15 day post administration observation period. Based on this result, the acute oral LD50 of the substance is considered to be greater than 5 g/kg bw.
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