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EC number: 684-597-9 | CAS number: 1072005-10-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11. - 13.04.1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- EG-Richtlinie 92/69/EWG
- Principles of method if other than guideline:
- Highest and only measured concentration: 2.7 mg/L
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- No details available.
- Vehicle:
- no
- Details on test solutions:
- The test item was prepared with deionised water (1g/L) and shaked for 18h. Thereafter the solution was filtrated and the DOC value determined.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Strain/clone: Straus, clone 5
- Age at study initiation: 24h
- Source: own breeding
- Age of parental stock: 2-3 days
- Feeding during test : no
ACCLIMATION
- Acclimation period: no, same as test conditions - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 19 - 21 °C
- pH:
- 7.8 - 8.1
- Dissolved oxygen:
- 8.2 - 8.5 mg/L
- Nominal and measured concentrations:
- Nominal concentration: 2.7 mg/L
Measured concentration: 2.3 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: erlenmeyer flask
- Material: glass
- Volume of solution: 10 mL
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: 2mL/animal
TEST MEDIUM / WATER PARAMETERS
- Preparation of dilution water: according to EG Richt1inie 92/69/EWG
CaC12 x 2 H2O: 294 mg/L
MgSO4 x 7 H2O: 123 mg/L
NaHCO3: 63 mg/L
KCl: 5.5 mg/L
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: dark
EFFECT PARAMETERS MEASURED: Immobility (after 24h and 48h)
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 2.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 2.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities:
no
- Other biological observations: no
- Mortality of control: no
- Other adverse effects control: no
- Immobilisation of control: no
- Abnormal responses: no
- Any observations that might cause a difference between measured and nominal values: no - Results with reference substance (positive control):
- - Results with reference substance valid?
yes
Two concentrations were measured: At 1 mg/L 35% of the Daphnids were immobilized, at 2 mg/L 100% of the Daphnids were immobilized. - Validity criteria fulfilled:
- yes
- Conclusions:
- In the Daphnia immbilisation test a EC50 value > 2.7 mg/L was determined.
- Executive summary:
The toxicity of the test item to Daphnia magna was determined according to the principles of OECD 202. The aim of the study was the determination of NOEC, LOEC, EC10- , EC20- and EC50-values of immobilsation over a period of 48 hours. The study was conducted under static conditions. A stock solution of 1 g/L was prepared with deionised water. One concentration was tested: 2.7 mg/L. Five replicates were tested for the test item concentration and for the control. The environmental conditions were within the acceptable limits. The concentrations of the test item in the test concentration and the control were analytically verified by TOC Infrared analyser at the start and the end of exposure. The measured concentrations were in the range of 20 % of the nominal value. Therefore, all effect values given are based on the nominal test item concentrations. No immobilistion was observed. The following results were determined: EC50 >2.7 mg/L, NOEC = 2.7 mg/L, LOEC > 2.7 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12. - 15.05.1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- EG-Richtlinie 92/69/EWG
- Principles of method if other than guideline:
- Highest and only measured concentration: 2.0 mg/L
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 853947-59-8
- Analytical monitoring:
- no
- Details on sampling:
- The analytical determination of the stability of the test item was tested separately. Concentrations of 0.5, 1.2 and 2.4 mg/L were analyzed after 24, 48 and 72 h. The recovery rate was >80%, therefore nominal values were used for the test. Determination of Carbon with a TOC-500 Infrared analyser. No additional details available. During the test no concentrations were measured.
- Vehicle:
- no
- Details on test solutions:
- The test item was prepared with deionised water (1g/L) and shaked for 18h. Thereafter the solution was filtrated and the DOC value determined.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Strain/clone: Straus, clone 5
- Age at study initiation: 24h
- Source: own breeding
- Age of parental stock: 2-3 days
- Feeding during test : no
ACCLIMATION
- Acclimation period: no, same as test conditions - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 19 - 21 °C
- pH:
- 7.9 - 8.0
- Dissolved oxygen:
- 7.7 - 8.1 mg/L
- Nominal and measured concentrations:
- Nominal concentration: 2.0 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: erlenmeyer flask
- Material: glass
- Volume of solution: 10 mL
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: 2mL/animal
TEST MEDIUM / WATER PARAMETERS
- Preparation of dilution water: according to EG Richt1inie 92/69/EWG
CaC12 x 2 H2O: 294 mg/L
MgSO4 x 7 H2O: 123 mg/L
NaHCO3: 63 mg/L
KCl: 5.5 mg/L
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: dark
EFFECT PARAMETERS MEASURED: Immobility (after 24h and 48h)
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities:
no
- Other biological observations: no
- Mortality of control: no
- Other adverse effects control: no
- Immobilisation of control: no
- Abnormal responses: no
- Any observations that might cause a difference between measured and nominal values: no - Results with reference substance (positive control):
- - Results with reference substance valid?
yes
Two concentrations were measured: At 1 mg/L 40% of the Daphnids were immobilized, at 2 mg/L 100% of the Daphnids were immobilized. - Validity criteria fulfilled:
- yes
- Conclusions:
- In the Daphnia immbilisation test a EC50 value > 2.0 mg/L was determined.
- Executive summary:
The toxicity of the test item to Daphnia magna was determined according to the principles of OECD 202. The aim of the study was the determination of NOEC, LOEC, EC10- , EC20- and EC50-values of immobilsation over a period of 48 hours. The study was conducted under static conditions. A stock solution of 1 g/L was prepared with deionised water. One concentration was tested: 2.0 mg/L. Five replicates were tested for the test item concentration and for the control. The environmental conditions were within the acceptable limits. The analytical determination of the stability of the test item was tested separately. Concentrations of 0.5, 1.2 and 2.4 mg/L were analyzed after 24, 48 and 72 h. The recovery rate was >80%, therefor nominal values were used for the test. During the test no concentrations were measured. No immobilistion was observed. The following results were determined: EC50 >2.0 mg/L, NOEC = 2.0 mg/L, LOEC > 2.0 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to chapter 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 2.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 2.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to chapter 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Referenceopen allclose all
Description of key information
No data on the test item is available. With the read-across substances the following results were obtained:
CAS 68583-51-7: EC50 >2.7 mg/L, NOEC = 2.7 mg/L
CAS 853947-59-8:EC50 >2.0 mg/L, NOEC = 2.0 mg/L
Key value for chemical safety assessment
Additional information
No data on the test item is available. With the read-across substances the following results were obtained:
The toxicity of the read-across substance CAS 68583-51-7 to Daphnia magna was determined according to the principles of OECD 202. The aim of the study was the determination of NOEC, LOEC, EC10- , EC20- and EC50-values of immobilsation over a period of 48 hours. The study was conducted under static conditions. A stock solution of 1 g/L was prepared with deionised water. One concentration was tested: 2.7 mg/L. Five replicates were tested for the test item concentration and for the control. The environmental conditions were within the acceptable limits. The concentrations of the test item in the test concentration and the control were analytically verified by TOC Infrared analyser at the start and the end of exposure. The measured concentrations were in the range of 20 % of the nominal value. Therefore, all effect values given are based on the nominal test item concentrations. No immobilistion was observed. The following results were determined: EC50 >2.7 mg/L, NOEC = 2.7 mg/L, LOEC > 2.7 mg/L.
The toxicity of the read-across substance 853947-59-8 to Daphnia magna was determined according to the principles of OECD 202. The aim of the study was the determination of NOEC, LOEC, EC10- , EC20- and EC50-values of immobilsation over a period of 48 hours. The study was conducted under static conditions. A stock solution of 1 g/L was prepared with deionised water. One concentration was tested: 2.0 mg/L. Five replicates were tested for the test item concentration and for the control. The environmental conditions were within the acceptable limits. The analytical determination of the stability of the test item was tested separately. Concentrations of 0.5, 1.2 and 2.4 mg/L were analyzed after 24, 48 and 72 h. The recovery rate was >80%, therefor nominal values were used for the test. During the test no concentrations were measured. No immobilistion was observed. The following results were determined: EC50 >2.0 mg/L, NOEC = 2.0 mg/L, LOEC > 2.0 mg/L.
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