Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 214-507-1 | CAS number: 1137-42-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06 Dec 2018 to 18 Dec 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Version / remarks:
- 2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187 “Particle Size Analysis by Laser Diffraction”
- Version / remarks:
- Handbook K, 2007
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of particle tested:
- agglomerate
- Type of distribution:
- volumetric distribution
- Specific details on test material used for the study:
- Appearance: White crystals
EC number: 214-507-1
CAS number: 1137-42-4
Purity: 99.72%
Test item storage: At room temperature, desiccated
Relative density: 1.30 (supplied by Charles River Laboratories) - Mass median aerodynamic diameter:
- 73 µm
- Geometric standard deviation:
- 2.747
- Key result
- Percentile:
- other: Volume Weighted Mean
- Mean:
- 83.7 µm
- Remarks on result:
- other: VWM
- Remarks:
- Using the identified parameters, the particle size was analysed over the range 0.01 µm to 3500 µm.
- Key result
- Percentile:
- other: Mode
- Mean:
- 101 µm
- Remarks on result:
- other: Mode
- Remarks:
- Using the identified parameters, the particle size was analysed over the range 0.01 µm to 3500 µm.
- Key result
- Percentile:
- D10
- Mean:
- 13.2 µm
- St. dev.:
- 0.194
- Key result
- Percentile:
- D50
- Mean:
- 64 µm
- St. dev.:
- 1.26
- Key result
- Percentile:
- D90
- Mean:
- 185 µm
- St. dev.:
- 4.86
- Conclusions:
- The D50 of this substance was shown to be 64 µm.
- Executive summary:
In this guideline study, performed with GLP certification, the test item 4 -hydroxybenzophenone was shown to have a particle size distribution D50 of 64 µm.
Reference
During the method development phase of the analysis trials were conducted using both the dry powder module and the small volume (wet) module. The small volume module trials were conducted using silicone oil as the dispersant. The small volume module trials did not give reproducible results and the dry powder module was therefore used in the final analysis. The results of the trials indicated that the most appropriate test and material parameters to obtain the optimum measurements were:
Module : Dry powder module
Dispersant : Air
Dispersion pressure : 0.0 barg
Refractive index (sample) : 1.500 n
Absorption : 0.010 AU
Analysis Model : General Purpose
Using the identified parameters, the particle size was analysed over the range 0.01 µm to 3500 µm. The results of the formal analysis are presented in Table 9:1. In addition, a graph of volume (%) versus Particle Diameter (µm), and full particle size distribution, is provided in Graph 9.A (Average of 5 runs).
The full table of results can be found attached below.
Description of key information
Study conducted to recognised testing guidelines with GLP certification.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.