Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 238-056-5 | CAS number: 14205-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November - December 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Test item code: LZ937.00
Expiration date: 21 May 2000
Delivery date: 11 October 1999
Test material was stored at ambient temperature in the dark.
Physical state: White crystalline solid
Storage conditions: Stored at ambient temperature in the dark - Oxygen conditions:
- anaerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- Source: Haddington Sewage Works
A local sewage processing plant which handles predominantly domestic sewage.
Received: 16 November 1999
The activated sludge was well mixed prior to sampling for solids content determination. The solids content of the sludge was determined as 3.7 g solids per litre sludge. The sludge was then allowed to settle for at least 30 minutes prior to a sample of the supernatant being withdrawn for use as the test microbial inoculum. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 38.4 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- A totally sealed system was constructed supplied on a positive pressure basis by CO2 free air. CO2 was removed by passing through self-indicating soda lime granules contained in a glass trap. The CO2 free air was then passed through the bioreactor set-ups and exited the system through non-return valves. A total of 6 bioreactors (2 litre capacity) were used 2 for LZ937, 2 controls, 1 for the reference material and 1 for the toxicity control.
The test material bioreactors each contained 1930 ml of mineral media, 20 ml of microbial inoculum and 50 ml of test material stock. The reference material bioreactor contained 1910 ml of mineral media, 20 ml of microbial inoculum and 69 ml of reference material stock. The control bioreactors each contained 1980 ml of mineral media and 20 ml of microbial inoculum. The toxicity control bioreactor contained 1860 ml of mineral media, 50 ml test material stock, 69 ml reference material stock and 20 ml of microbial inoculum. Each bioreactor was connected to three traps, each trap containing 100 ml 0.0125M Ba(OH)2. At a trap collection the trap closest to the bioreactor was taken for titration and the two remaining traps were then moved towards the bioreactor. A new trap containing freshly prepared Ba(OH2) was then placed third in line from the bioreactor. Trap changes were conducted on Days 2, 5, 7, 9, 12, 14, 19, 23 and 29. During these trap changes the vacuum system was switched off to allow a trap changeover to be conducted. All sampled traps were then titrated. Each trap sample was titrated against 0.05 M HCI utilising the colour change from pink to colourless with phenolphthalein indicator of which a few drops were added to each trap. The pH was determined (Jenway 3071 pH meter) in each bioreactor at Days 0, 28 and 29. The pH was adjusted on Day 0, to values between 7.2 and 7 .6. On Day 28 concentrated HCI was added to the bioreactors to acidify and drive off residual CO2 overnight. - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- Batch 9746702 197)
- Test performance:
- In this test LZ937 commenced biodegradation activity after day 2, and had biodegraded by 61.6 % on day 12. As LZ937 had achieved over 60%
biodegradability within the 10 day window it can be concluded that LZ937 is readily biodegradable under the conditions of the test. - Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 69.7
- Sampling time:
- 28 d
- Details on results:
- The results of the toxicity control indicated a potential slight reduction (20 % inhibition) of microbial activity in the presence of the LZ937. Titrations during the period of biodegradation activity were within 20% of the mean values. There was a penetration of CO2 into the test system after day 23 of this test, however as the 10 day window for both test and reference materials had been identified, this penetration of CO2 into the system later in the test is not considered to affect the validity of the test. The penetration of CO2 into the system after day 23 resulted in high control CO2 production in day 29 results. However prior to this point the control CO2 production was low. With the exception of exceeding the limit of CO2 production in the controls at day 29, all validity criteria were met. The pH of the bioreactors was measured at the end of the test.
- Results with reference substance:
- The reference material was readily biodegradable, 75.6 % biodegradability was achieved by day 9 in this test and a cumulative total of 113.2 % was achieved by test termination.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- As the test item has achieved over 60% biodegradability within the 10 day window it can be concluded that ACMe is readily biodegradable under the conditions of the test.
- Executive summary:
The ready biodegradability of ACMe was assessed over a 28 day period by the Modified Sturm Test. The test was performed according to OECD Guideline 301 B, in year 1999. A total of 6 bioreactors were used, two vessels each for LZ937 and controls, 1 each for the reference material and toxicity control. In this test, ACMe commenced biodegradation activity after day 2, and had biodegraded by 61.6 % on day 12. As the substance had achieved over 60 %
biodegradability within the 10day window it can be concluded that ACMe is readily biodegradable under the conditions of the test. The reference material was readily biodegradable, 75.6 % biodegradability was achieved by day 9 in this test and a cumulative total of 113.2 % was achieved by test termination.
Reference
Modified Sturm Test, Cumulative % Biodegradation for Test and Reference Materials and Toxicity Control:
Day No. |
Test material LZ937 |
Reference Material Sodium Benzoate |
Toxicity Control |
2 |
0.6 |
21.3 |
15.5 |
5 |
28.8 |
47.8 |
32.2 |
7 |
49.3 |
66.5 |
49.7 |
9 |
59.9 |
75.6 |
60.4 |
12 |
61.6 |
81.6 |
61.8 |
14 |
64.1 |
91.7 |
63.6 |
19 |
67.3 |
103.7 |
65.4 |
23 |
69.7 |
113.2 |
66.9 |
29 |
69.7 |
113.2 |
66.9 |
Description of key information
As the test item has achieved over 60% biodegradability within the 10 day window it can be concluded that ACMe is readily biodegradable under the conditions of the test.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.