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EC number: 947-850-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 May - 14 Jun 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Activated sludge was collected on 13 May 2005 from the municipal waste water treatment plant Neustadt/Weinstrasse, Lachen-Speyerdorf
- Method of cultivation: The sludge was continuously aerated and washed with tap water and OECD medium
- Concentration of suspended solids: 12.78 g/L - Duration of test (contact time):
- 28 d
- Initial conc.:
- 20 mg/L
- Based on:
- other: TOC
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral medium as recommended by the guideline
- Test temperature: 21 ± 1 °C
- Aeration of dilution water: All vessels were aerated overnight with CO2-free air prior to test start and during the test
- Suspended solids concentration: 25 mg/L
TEST SYSTEM
- Culturing apparatus: 2 L Glass bottles, 1500 mL fill volume
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: Aeration with CO2-free air
- Details of trap for CO2: Outgoing air from the test vessels passed two serial bottles containing 0.25 M NaOH solution
- Other:
SAMPLING
- Sampling frequency: Measurement of evolved CO2 on days 2, 4, 6, 8, 10, 14, 21, 28 and 29
- Sampling method: 0.5 mL aliquots of the NaOH solution was sampled at each time point and analysed using a TOC 5050A (Shimadzu)
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2 vessels
- Abiotic sterile control: 1 vessel
- Toxicity control: 1 vessel - Reference substance:
- aniline
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 85.2
- Sampling time:
- 28 d
- Details on results:
- - The toxicity control attained 98.3% degradation.
- Abiotic degradation was 26.6%. - Results with reference substance:
- The reference substance attained 79.9% degradation after 28 days.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to analogue approach justification provided in IUCLID section 13.
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 85.2
- Sampling time:
- 28 d
- Remarks on result:
- other:
- Remarks:
- Source: RA-A, EC 701-177-3, LAUS, 05041406J605, 2005, CO2 Evolution
- Conclusions:
- The target substance is readily biodegradable based on experimental results with a structurally and chemically closely related source substance (85.2% in 28 d, OECD 301 B); read-across
Referenceopen allclose all
Table 1: Percentage of Degradation
Day |
% Degradation |
|||
Reference |
Test Item (mean of duplicates) |
Abiotic Control |
Toxicity Control |
|
2 |
2.6 |
1.7 |
3.4 |
3.2 |
4 |
26.5 |
24.1 |
3.1 |
53.5 |
6 |
56.1 |
47.5 |
11.3 |
68.7 |
8 |
66.5 |
57.4 |
16.0 |
75.8 |
10 |
71.1 |
61.3 |
8.6 |
79.7 |
14 |
76.2 |
72.9 |
17.6 |
86.7 |
21 |
85.0 |
88.3 |
22.9 |
97.5 |
28 |
77.6 |
83.0 |
28.0 |
99.6 |
29 |
79.9 |
85.2 |
26.6 |
98.3 |
Description of key information
Readily biodegradable: 85.2% in 28 d (OECD 301 B, activated sludge); read-across
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
There is no experimental study available, in which the ready biodegradability of the target substance Reaction mass of N-(1-oxooctadecyl)sarcosine and N-hexadecanoyl-N-methylglycine (EC 947-850-7) was assessed. Therefore, read-across to the structurally and chemically closely related source substance N-methyl-N-[C18-(unsaturated)alkanoyl]glycine (EC 701-177-3) was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 in order to fulfill the standard data requirements for the target substance.
Based on the structural and chemical similarity of the target and source substance, the selected source substance is considered a suitable representative for the assessment of the ready biodegradability of the target substance, in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. A detailed analogue justification is provided in IUCLID section 13.
The available study with the source substance N-methyl-N-(C18-(unsaturated)alkanoyl)glycine (EC 701-177-3) was performed according to the OECD guideline 301 B using non-adapted activated sludge from a municipal waste water treatment plant. 20.0 mg/L test item (based on total organic carbon content) was inoculated with 25 mg/L activated sludge (suspended solids) for 28 d under aeration with CO2-free air. Inoculum blanks, an abiotic sterile control and a toxicity control were run in parallel. CO2 was trapped in bottles containing 0.25 M NaOH solution and the evolution of CO2 concentrations was followed by TOC analysis in regular intervals.
After 28 d incubation, the test item was degraded by 85.2% in terms of CO2 evolution and the 10-day window was met. Thus, the substance is readily biodegradable according to the OECD criteria.
Based on the structural and chemical similarity of the target and source substance, the target substance is expected to exhibit a similar environmental fate profile as the selected source substance. Therefore, it is concluded that the target substance Reaction mass of N-(1-oxooctadecyl)sarcosine and N-hexadecanoyl-N-methylglycine (EC 947-850-7) is readily biodegradable according to OECD guideline criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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