Registration Dossier
Registration Dossier
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EC number: 201-145-4 | CAS number: 78-81-9
Endpoint summary
Administrative data
Description of key information
Aquatic toxicity studies were conducted at the three trophic levels; algae, invertebrates and fish.
In a publication showing that the fish embryo tests are neither better nor worse than acute fish toxicity tests and provide strong scientific support for the FET as a surrogate for the acute fish toxicity test, results in reference to Brust 2001 mention that a 48h exposure of isobutylamine to Danio rerio embryo lead to a LC50 value of 92.6 mg/L.
Aquatic toxicity of isobutylamine to invertebrate (Daphnia magna) was determined in a static 48 -hour Immobilisation GLP test with closed vessel design according to OECD 202 guideline. The 48-hour NOEC was determined to be ≥ 85.0 mg test item/L. The 48-hour LOEC was determined to be > 85.0 mg test item/L and the 48-hour EC10,20,50 values were also determined to be > 85.0 mg test item/L.
Toxicity of isobutylamine to R. subcapitata was tested in an algal growth inhibition GLP test with closed vessel design according to OECD guideline 201.The 96-hour ErC50value was calculated to be 4.2 mg test item/L, the 96-hour EbC50was calculated to be 1.2 mg test item/L and the 96-hour EyC50was calculated to be 1.3 mg test item/L. The 96-hour NOErC was determined to be 0.639 and the associated 96-hour LOErC was 2.79 mg/L. The 96-hour NOEbC was determined to be 0.067 and the associated 96-hour LOEbC was 0.180 mg/L. The 96-hour NOEyC was determined to be < 0.067 and the associated 96-hour LOEyC was 0.067 mg/L.
Additional information
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