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Diss Factsheets
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EC number: 441-070-6 | CAS number: 61826-76-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 441-070-6
- EC Name:
- -
- Cas Number:
- 61826-76-4
- Molecular formula:
- C14H11NO2
- IUPAC Name:
- (2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
- Remarks:
- water
- Details on test solutions:
- Immediately before the beginning of the test a 20 mg/L solution was prepared by dissolving 5.2 mg test substance in 250 mL reconstituted water. The appropriate concentrations were then obtained by diluting with reconstituted water.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Neonates of Daphnia magna, less than 24 hours old, were obtained by hatching ephippia, supllied in the microbiotest Daphtoxkit F.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 250 mg CaCO3/L
- Test temperature:
- 20 °C
- Nominal and measured concentrations:
- Nominal concentrations: 0, 0.10, 0.18, 0.32, 0.56 and 1.00 mg/L
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 0.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 0.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
Any other information on results incl. tables
Comments:
Due to the rapid hydrolysis the determination of the test
substance concentration was not possible. At the beginning
of the test, the test substance concentrations were already
below the detection limit of 0.2 mg/L.
The concentrations of the hydrolysis product were therefore
also determined and were stable between the begin and the
end of the test.
Results:
- Immobilisation of control group daphnids was 0% at the end of the tests (guideline maximum of 10%)
- There were no control daphnids trapped at the water surface
- Temperature was stable during the test period
- Dissolved oxygen concentrations in the test vessels were not lower than 8.5 mg/L (EC guideline: higher than 3.5 mg/L)
- The concentrations of the hydrolysis product were stable between the begin and the end of the test.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- For the static acute immobilization test with Daphnia magna conducted according to EU method C.2 the following effect concentrations were determined after treatment with the test item:
- 48 h EC50: 0.9 mg/L (95% confidence limit (upper 1.2, lower 0.8)
- 48h EC0: 0.6 mg/L. - Executive summary:
For the static acute immobilization test with Daphnia magna conducted according to EU method C.2 the following effect concentrations were determined after treatment with the test item:
- 48 h EC50: 0.9 mg/L (95% confidence limit (upper 1.2, lower 0.8)
- 48h EC0: 0.6 mg/L.
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