Isopropyl nitrite

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro gene mutation study in bacteria

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Mutagenicity of some alkyl nitrites used as recreational drugs

Author:

Virginia C. Dunkel, Andrea M. Rogers-Back, Timothy E. Lawlor, John W. Harbell, and Thomas P. Cameron

Year:

1989

Bibliographic source:

Food and Drug Administration, Washington, DC, National Cancer Institute, National Institutes of Health, Bethesda and Microbiological Associates Inc., Rockville

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 471 (Bacterial Reverse Mutation Assay)

GLP compliance:

not specified

Type of assay:

bacterial reverse mutation assay

Test material

Test material information

Constituent 1

Reference substance name:

''amyl nitrite'', mixed isomers

EC Number:

203-770-8

EC Name:

''amyl nitrite'', mixed isomers

Cas Number:

110-46-3

Molecular formula:

C5H11NO2

IUPAC Name:

3-methylbutyl nitrite

Method

Species / strain

Species / strain / cell type:

S. typhimurium TA 1535, TA 1537, TA 98 and TA 100

Metabolic activation:

with and without

Results and discussion

Test results

Test results 1

Key result

Species / strain:

S. typhimurium TA 1535

Metabolic activation:

with and without

Genotoxicity:

positive

Cytotoxicity / choice of top concentrations:

not specified

Test results 2

Key result

Species / strain:

S. typhimurium TA 100

Metabolic activation:

with

Genotoxicity:

positive

Cytotoxicity / choice of top concentrations:

not specified