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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 947-962-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of the inhalation of a surface tension-reducing substance (propylene glycol) ono the ultrastructure of the epithelium of the respiraatoy passages in rabbits
- Author:
- Konradova V., Vavrova V., Janota J.
- Year:
- 1 978
- Bibliographic source:
- Folia Morphologica 26, 28-34
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Six rabbits were exposed for either 20 or 120 minutes to an aerosol of monopropylene glycol (10% in air). In each experimental group the tracheal epithelium of 3 rabbits was examined.
- GLP compliance:
- no
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Propane-1,2-diol
- EC Number:
- 200-338-0
- EC Name:
- Propane-1,2-diol
- Cas Number:
- 57-55-6
- Molecular formula:
- C3H8O2
- IUPAC Name:
- propylene glycol
- Details on test material:
- Source: Dow Chemical company, Freeport, Texas
Purity: 99%
Appearance: clear liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Weight at study initiation: 2000-3000 mg
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus:TRI-airborne infection apparatus
- Source and rate of air: 10 l air/minute
- System of generating particulates/aerosols: glass inhalator by Synek - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- >= 20 - <= 120 min
- Remarks on duration:
- Exposure duraction was either 20 min or 2 hours
- Concentrations:
- 10% monopropylene glycol in air (100000 ppm, 317041 mg/m3)
- No. of animals per sex per dose:
- 3 per dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 317 042 mg/m³ air
- Exp. duration:
- 2 h
- Other findings:
- 20 minutes inhalation of 10% propylene glycol produced minimal alteration of ciliated cells, but it represented a strong secretory impuls for the goblet ones. After shorter inhalation 16.5% of goblet cells filled with large pale mucous granules, 31% of mucus discharging and 52% of completely exhausted ones with highly electron dense degenerated cytoplasm were observed. After 2 hours inhalation of monopropylene glycol signs of ciliated cells' alteration were more pronounced and a slight drop in the number of intact mucus filled (12%) and mucus discharging goblet cells (19%) was accompanied by an increase in the number of exhausted degenerated ones (69%). The degenerated goblet cells were gradually expelled from the epithelium. Even after 2 hours' inhalation the signs of increased differentiation of new goblet cells were not noticed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
The test substance has an inhalation LD50 > 317 042 mg/m³ air.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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