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Diss Factsheets
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EC number: 915-335-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin corrosion: Not corrosive based on an OECD TG 404 test.
Skin irritation: Not irritating based on an OECD TG 404 test.
Eye irritation: Not irritating based on an OECD TG 405 test.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin Irritation
In a skin irritation/corrosion study, performed similar to OECD 404 and following GLP principles, four female New Zealand white rabbits were exposed to 0.5 ml of undiluted test material and 0.5 ml of a 50% solution under semi-occlusive conditions. After 4 hours, the test substance was removed by gentle swabbing with cotton wool soaked in warm water, and animals were observed for 7 days. Following 4-hour treatment with the undiluted material, the mean erythema scores of the four rabbits were 2 for all rabbits (mean scores 24, 48, and 72 hours after removal of the substance). The mean oedema scores over this time period were 2, 1.67, 2, and 2, respectively. Most of the effects were not reversible within 7 days. Based on the edema and erythema scores being <2.3 (but higher than 1.5), the substance is considered not to be corrosive or an irritant.
Eye Irritation
In an eye irritation study, performed similar to OECD 405 and following GLP principles, 0.1 mL of undiluted test substance was applied to six rabbit eyes followed by examinations at 24-, 48 and 72-hours and at day 7 days following treatment. The following results were obtained and expressed as mean scores 24, 48, and 72 hours after removal of the substance: Corneal opacity (score 1) was observed in 2 out of 6 animals. Iritis (Score 0.33) was observed in 3 out of 6 animals. Conjunctivae redness was observed in 5 out of 6 animals with scoring of 0.33, 0.67, 1 (2 animals), and 2, respectively. Chemosis was observed in 4 out of 6 animals with scoring of 0.33 (2 animals), and 1.33 (2 animals). All effects were cleared with 7 days. The substance is not considered to be an eye irritant.
Justification for classification or non-classification
Based on the results of the available skin and eye irritation in vivo studies, classification of the substance for skin and eye irritation is not warranted according to EU CLP (EC 1272/2008 and its amendments).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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