Decan-1-ol

Toxicity to reproduction

Administrative data

Endpoint:

screening for reproductive / developmental toxicity

Type of information:

other: collection of data

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference 1

Reference Type:

other: collection of data

Title:

Query: Records containing the term 1-DECANOL as displayed on http://toxnet.nlm.nih.gov on December 21, 2018.

Author:

Hazardous Substances Data Bank (HSDB)

Reference 2

Reference Type:

publication

Title:

Developmental Toxicology Assessment of 1-Octanol, 1-Nonanol, and 1-Decanol Administered by Inhalation to Rats

Author:

Nelson BK et al.

Year:

1990

Bibliographic source:

Nelson BK et al; J Am Coll Toxicol 9 (1): 93-7 (1990)

Materials and methods

GLP compliance:

not specified

Test material

Test material information

Test material form:

liquid

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

female

Results and discussion

Any other information on results incl. tables

Fifteen pregnant female Sprague-Dawley rats were exposed for 7 hr/day on gestation days 1-19 (sperm = 0) to one of three long-chain alcohols at the maximum concn that could be generated as a vapor. These concentrations were 400 mg/cu m 1-octanol, 150 mg/cu m 1-nonanol, and 100 mg/cu m1-decanol. Dams were weighed daily for the first week of exposure, and weekly thereafter. On gestation day 20, rats were sacrificed. Fetuses were serially removed, blotted dry, examined for external malformations, sexed, weighed, placed in appropriate fixatives, and subsequently examined for visceral or skeletal abnormalities. No treatment-related effects were observed in pregnant females, frequency of resorptions, fetal weights, or skeletal/visceral malformations. Thus, long-chain alcohols at these vapor concn appear not to be toxic as evidenced by these fetal and maternal parameters.