Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-613-9 | CAS number: 144-02-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1961
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- unsuitable test system
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of temperature on toxicity and distribution of pentobarbital and barbital in rats and dogs.
- Author:
- SETNIKAR I, TEMELCOU O.
- Year:
- 1 961
- Bibliographic source:
- Journal of Pharmacology and Experimental Therapeutics. Vol. 135, Pg. 213, 1962.
Materials and methods
- Objective of study:
- other: blood level
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Remarks:
- pre-GLP
Test material
- Reference substance name:
- Barbital sodium
- EC Number:
- 205-613-9
- EC Name:
- Barbital sodium
- Cas Number:
- 144-02-5
- Molecular formula:
- C8H11N2O3.Na
- IUPAC Name:
- sodium 5,5-diethyl-4,6-dioxo-1,4,5,6-tetrahydropyrimidin-2-olate
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- dog
- Strain:
- other: Mongrel
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Male mongrel dogs, with a body weight of 6 to 15 kg, were used. Each dog was subjected to two experiments with a 7-day interval between them. In one, 12 hours before and after the injection of the barbiturate, the animal was kept at a room temperature of 15 ±1°C, in the other the dog was kept at 30 ± 1°C. This order was alternated so that half the dogs underwent the experiments in the cold environment first and half underwent the experiment in the warm environment first.
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Details on exposure:
- Male mongrel dogs, with a body weight of 6 to 15 kg, were injected intravenously with the barbiturates. Each dog was subjected to two experiments with a 7-day interval between them. In one, 12 hours before and after the injection of the barbiturate, the animal was kept at a room temperature of 15 ±1°C, in the other the dog was kept at 30 ± 1°C. This order was alternated so that half the dogs underwent the experiments in the cold environment first and half underwent the experiment in the warm environment first. Averages of the barbital sodium blood levels observed at 10/20/30/40/60/90/120/180/240/300 minutes in six dogs kept at 30°C and at 15°C room temperature after an intravenous injection of 150 mg/kg of the drug were obtained.
Doses / concentrations
- Dose / conc.:
- 150 other: mg/kg bw
- No. of animals per sex per dose / concentration:
- 6 dogs per group
- Details on dosing and sampling:
- Averages of the barbital sodium blood levels observed at 10/20/30/40/60/90/120/180/240/300 minutes in six dogs kept at 30°C and at 15°C room temperature after an intravenous injection of 150 mg/kg of the drug were obtained. The barbital in the blood was determined by the method of Goldbaum (1948)as modified by Broughton (1956).
- Statistics:
- The straight-lines were calculated by the least squares method on the basis of the barbital blood levels observed from the 20th minute onwards. By analysis of the variance, the variance within the animals was separated and only this was considered for calculating the standard error of the slope function and of the straight-line constant.
Results and discussion
Main ADME resultsopen allclose all
- Type:
- other: blood level
- Results:
- log mg/I = (2.332 ±0.003) - (2.212 ± 0.348)* 10^-4min (at 15°C room temperature)
- Type:
- other: blood level
- Results:
- log mg/I = (2.331 ±0.003) - (3.254 ± 0.285)* 10^-4min (at 30°C room temperature)
Any other information on results incl. tables
Barbital sodium blood levels: No significant difference was found at the two temperatures for the slope functions or for the intersection point with the time = 0 ordinate (2.331 ± 0.004 at 15°C room temperature and 2.332 ± 0.005 at 30°C).
Applicant's summary and conclusion
- Executive summary:
The barbital sodium blood levels observed in six dogs kept at 30°C and at 15°C room temperature after an intravenous injection of 150 mg/kg of the drug were determined.
Male mongrel dogs, with a body weight of 6 to 15 kg, were injected intravenously with the barbiturates. Each dog was subjected to two experiments with a 7-day interval between them. In one, 12 hours before and after the injection of the barbiturate, the animal was kept at a room temperature of 15 ± 1°C, in the other the dog was kept at 30 ± 1°C. This order was alternated so that half the dogs underwent the experiments in the cold environment first and half underwent the experiment in the warm environment first.
Two straight lines were calculated by the least squares method on the basis of the barbital blood levels observed from the 20th minute onwards: log mg/I = (2.332 ±0.003) - (2.212 ± 0.348)* 10^-4min (at 15°C room temperature), log mg/I = (2.331 ±0.003) - (3.254 ± 0.285)* 10^-4min (at 30°C room temperature).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.