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Diss Factsheets
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EC number: 944-119-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Toxicokinetics of the registered substance is based on the properties of the constituents.
Nitric acid is only bioavailable in the form of nitrates due to immediate disintegration in physiological media. Nitrates are well absorbed and excreted mainly via urine.
Citric acid is of low relevance for the toxicokinetic assessment.
Tin:
Absorption:
The amount of tin absorbed into the bloodstram depends on the solubility of the compound as well as the oxidation state of the tin entity. Tin(II) compounds are more readily absorbed than tin(IV) compounds. However, overall tin absorption via the GI tract is low [WHO 1980]. In a toxicokinetics study, rats were given radiolabelled Sn(II) or Sn(IV) in the form of citrate or fluoride in a dose of 20 mg/kg bw. Absorption was estimated to be 2.85% for Sn(II) and 0.64% for Sn(IV) [WHO 1980].
No information is available on tin absorption following dermal or inhalation exposure.
Distribution:
"Inorganic tin distributes mainly to bone, but also to the lungs, liver, kidneys, spleen, lymph nodes, tongue, and skin. [...] Following a single gavage dose of 20 mg/kg body weight of radiolabelled 113Sn(II) or 113Sn(IV) as the fluoride or citrate, the tissue distribution of tin in rats after 48 h as a percentage of the administered tin(II) or tin(IV), respectively, was as follows: skeleton, 1.0% and 0.24%; liver, 0.08% and 0.02%; and kidneys, 0.09% and 0.02%. When oral tin doses of 20 mg/kg body weight were given on 6 days/week for 4 weeks, only the bone contained higher tin concentrations after day 28 than after day 1. The half-time of tin in the femur was estimated to be 34–40 days. The investigator concluded that, of the soft tissues, only liver and kidneys are likely to accumulate significant amounts of tin as a result of the oral ingestion of tin salts. No 113Sn was found in the brain of rats 48 h following administration of 113Sn(II) or 113Sn(IV) as citrate or fluoride as a single oral dose (4 mg), as oral doses of 20 mg/kg body weight on 6 days/week for 4 weeks, or as a single intravenous dose (0.4 mg)" [WHO 1980].
Excretion:
The majority of ingested tin is not absorbed and excreted via the feces, while the absorbed fraction is excreted via urine. Especially tin(IV) compounds are hardly found in the bile, thus being almost exclusively excreted via the urine.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.