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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 701-129-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable in vitro testing method in pre-validation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
- Principles of method if other than guideline:
- The principle of the testing method is based on the fact that measuring the amount of proteins with nucleophilic side chains such as cysteine or lysine residues after incubation with putative allergens may serve as surrogate markers for chemical reactivity associated with allergenic potency. In the Direct Peptide Reactivity Assay (DPRA) the reactivity of a test item towards synthetic cysteine (C)- or lysine (K)-containing peptides is evaluated. For this purpose the test substance is incubated with synthetic peptides for 24 hours at room temperature and the remaining non-depleted peptide concentration is determined by high performance liquid chromatography (HPLC) with gradient elution and UV-detection at 220 nm. The peptides are custom material containing phenylalanine to facilitate UV-detection and either cysteine or lysine as the reactive center.
- GLP compliance:
- no
- Remarks:
- In 2011, the method was still an in-house validated method.
- Type of study:
- other: Direct Peptide Reactivity Assay
Test material
- Details on test material:
- - Name of test material (as cited in study report): Plantapon LGC Sorb
- Physical state: liquid, yellowish, clear
- Analytical purity: 31.1%
- Lot/batch No.: CE02480006
Constituent 1
Results and discussion
- Positive control results:
- The positive control item p-benzoquinone showed a reactivity of 100% towards the cysteine-peptide and of 100% towards lysine-peptide. The mean reactivity for both depletions was 100%, indicating a high reactivity for this substance. Thus, as expected, the positive control substance was a strong sensitizer in the present in vitro assay.
In vitro / in chemico
Results
- Parameter:
- other: Migrated information from in vitro study
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: other: not applicable. Group: test group. Dose level: 100 mM. Clinical observations: The test item showed a reactivity of -4% towards the cysteine-peptide and of-0.2% towards lysine-peptide. The mean reactivity for both depletions was 0, indicating a minimal reactivity of the test item and thus, the test item was a non-sensitizer..
Any other information on results incl. tables
For the test substance the mean peptide depletion as average of cysteine- and lysine-peptide depletions is calculated and summarized in the table below (negative depletions were considered to be “0” for calculation of the mean peptide depletion):
Table1: Mean Peptide Depletion
Cysteine-Peptide | Lysine-Peptide | mean of both depletions | |||
[%] | SD | [%] | SD | [%] | |
p-Benzoquinone | 100 | 0.0 | 100 | 0.0 | 100.0 |
Plantapon LGC Sorb | -4.0 | 5.1 | -0.2 | 0.8 | 0.0 |
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- According to the classification tree model proposed by Gerberick et al. (2007), the test item was predicted to be a non sensitizer in the In vitro direct peptide reactivity assay.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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