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Diss Factsheets
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EC number: 201-741-4 | CAS number: 87-39-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity (LD50) of the target substance 5-hydroxyiminobarbituric acid were predicted using two QSAR applications, the OECD toolbox and the Danish QSAR database.
The OECD Toolbox predicted an oral LD50 value of 4570 mg/kg which do not meet the classification criteria. However, using the Danish QSAR database an LD50 value of 1300 mg/kg in rats (reliability index 0.34) and 1800 mg/kg in mice (reliability index 0.15) were obtained.
Due to lack of consistency and low reliability, data are not considered sufficient for a classification decision. However, there are no immediate alerts for acute toxicity of violuric acid.
See also QSAR summary attached in section 13.2
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- OECD Toolbox Version 4.1. The toolbox is a software application to identify and fill (eco)toxicology data gaps for chemical hazard assessment. The toolbox is developed in cooperation with OECD and ECHA. For reference see www.qsartoolbox.org
- Guideline:
- other: REACH Guidance on QSARs R.6.
- Specific details on test material used for the study:
- SMILES: ON=C1C(=O)NC(=O)NC1=O
- Dose descriptor:
- LD50
- Effect level:
- ca. 4 570 mg/kg bw
- Remarks on result:
- other:
- Remarks:
- QSAR predicted value
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Test substance is not acute toxic based on OECD Toolbox prediction and read-across
- Executive summary:
The OECD Toolbox version 4.1. was used for prediction of acute toxicity (LD50) and read-across were performed from related substances. Only the result in the applicability domain is accepted. The predicted LD 50 for the target substance 5-hydroxyiminobarbituric acid was 4570 mg/kg. Thus, the QSAR prediction does not indicate alert for acute toxicity in relation to classification.
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- Danish QSAR database is a software application to identify and fill (eco)toxicology data gaps for chemical hazard assessment. For reference see http://qsar.food.dtu.dk/
- Guideline:
- other: REACH Guidance on QSARs R.6.
- Specific details on test material used for the study:
- SMILES: C1(=O)C(=NO)C(=O)NC(=O)N1
- Dose descriptor:
- LD50
- Effect level:
- >= 1 300 - <= 1 800 mg/kg bw
- Remarks on result:
- other: Rat (1300 mg/kg bw) and mouse (1800 mg/kg bw)
- Remarks:
- QSAR predicted value
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Acute toxicity test of the test substance is non-conclusive due to low prediction reliability score given by the model..
- Executive summary:
The Danish QSAR database was used for prediction of acute oral toxicity (LD50) using ACD/ ToxSuite 2.95 software. The predicted LD50 for the target substance 5-hydroxyiminobarbituric acid was 1300 mg/kg in rats (reliability index 0.34) and 1800 mg/kg in mice (reliability index 0.15). Both the predictions were of poor quality reliability, i.e index: <0.3 = not reliable prediction quality and 0.3-0.5 = borderline prediction quality. Therefore, the results are non-conclusive.
Referenceopen allclose all
The OECD Toolbox version 4.1. was used for prediction of acute toxicity (LD50) and read-across were performed from related substances. Only the result in the applicability domain is accepted. The predicted LD 50 for the target substance 5-hydroxyiminobarbituric acid was 4570 mg/kg.
Thus, the QSAR prediction does not indicate alert for acute toxicity in relation to classification.
The Danish QSAR database was used for prediction of acute toxicity (LD50) and read-across were performed from related substances. The predicted LD50 for the target substance 5 -hydroxyiminobarbituric acid was 1300 mg/kg in rats (reliability index 0.34) and 1800 mg/kg in mice (reliability index 0.15).
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Non-conclusive.
Too weak evidence to make conclusions upon. In vivo testing needed (OECD 423).
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
The results from the two QSAR predictions are non-conclusive and too weak evidence to make conclusions upon. In vivo testing is needed and already in progress (OECD 423).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.