Registration Dossier
Registration Dossier
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EC number: 208-385-9 | CAS number: 526-18-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Information is obtained from QSAR process
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- 1. SOFTWARE: VEGA (version 1.1.3)
2. MODEL (incl. version number): Mutagenicity (Ames test) CONSENSUS model 1.0.1
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
O=C(Nc1ccc(O)cc1)c2ccccc2(O)
For SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL, APPLICABILITY DOMAIN and ADEQUACY OF THE RESULT please see the attached document "Mutagenicity Consensus Guide" in the field "Attached justification" where the QMRF is explained. - Reason / purpose for cross-reference:
- (Q)SAR model reporting (QMRF)
- Guideline:
- other: Mutagenicity (Ames test) CONSENSUS model 1.0.1
- Type of assay:
- other: QSAR prediction
- Specific details on test material used for the study:
- SMILES : O=C(Nc1ccc(O)cc1)c2ccccc2(O)
- Key result
- Species / strain:
- not specified
- Additional information on results:
- Prediction is NON-Mutagenic with a consensus score of 0.15, based on 4 models.
- Remarks on result:
- no mutagenic potential (based on QSAR/QSPR prediction)
- Conclusions:
- Prediction is NON-Mutagenic with a consensus score of 0.15 (low reliability), based on 4 models.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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