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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 500-230-6 | CAS number: 68698-70-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1-{[3-(diethylamino)propyl][3-(4-{2-[4-(3-{[3-(diethylamino)propyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)-2-hydroxypropyl]amino}-3-(4-{2-[4-(3-{[3-(diethylamino)propyl][3-(4-{2-[4-(3-{[3-(diethylamino)propyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)-2-hydroxypropyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)propan-2-ol
- Molecular formula:
- C89H140N8O12
- IUPAC Name:
- 1-{[3-(diethylamino)propyl][3-(4-{2-[4-(3-{[3-(diethylamino)propyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)-2-hydroxypropyl]amino}-3-(4-{2-[4-(3-{[3-(diethylamino)propyl][3-(4-{2-[4-(3-{[3-(diethylamino)propyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)-2-hydroxypropyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)propan-2-ol
- Reference substance name:
- 1-{[3-(diethylamino)propyl]amino}-3-(4-{2-[4-(3-{[3-(diethylamino)propyl]amino}-2-hydroxypropoxy)phenyl]propan-2yl}phenoxy)propan-2-ol
- Cas Number:
- 130431-04-8
- Molecular formula:
- C35H56N4O4
- IUPAC Name:
- 1-{[3-(diethylamino)propyl]amino}-3-(4-{2-[4-(3-{[3-(diethylamino)propyl]amino}-2-hydroxypropoxy)phenyl]propan-2yl}phenoxy)propan-2-ol
- Reference substance name:
- 1-{[3-(diethylamino)propyl][3-(4-{2-[4-(3-{[3-(diethylamino)propyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)-2-hydroxypropyl]amino}-3-(4-{2-[4-(3-{[3-(diethylamino)propyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)propan-2-ol
- Molecular formula:
- C62H98N6O8
- IUPAC Name:
- 1-{[3-(diethylamino)propyl][3-(4-{2-[4-(3-{[3-(diethylamino)propyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)-2-hydroxypropyl]amino}-3-(4-{2-[4-(3-{[3-(diethylamino)propyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)propan-2-ol
- Reference substance name:
- 1-(4-{2-[4-(3-{[3-(diethylamino)propyl][3-(4-{2-[4-(3-{[3-(diethylamino)propyl][3-(4-{2-[4-(3-{[3-(diethylamino)propyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)-2-hydroxypropyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)-2-hydroxypropyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)-3-{[3-(diethylamino)propyl][3-(4-{2-[4-(3-{[3-(diethylamino)propyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)-2-hydroxypropyl]amino}propan-2-ol
- Molecular formula:
- C116H182N10O16
- IUPAC Name:
- 1-(4-{2-[4-(3-{[3-(diethylamino)propyl][3-(4-{2-[4-(3-{[3-(diethylamino)propyl][3-(4-{2-[4-(3-{[3-(diethylamino)propyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)-2-hydroxypropyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)-2-hydroxypropyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)-3-{[3-(diethylamino)propyl][3-(4-{2-[4-(3-{[3-(diethylamino)propyl]amino}-2-hydroxypropoxy)phenyl]propan-2-yl}phenoxy)-2-hydroxypropyl]amino}propan-2-ol
- Reference substance name:
- 2-piperazin-1-ylethylamine
- EC Number:
- 205-411-0
- EC Name:
- 2-piperazin-1-ylethylamine
- Cas Number:
- 140-31-8
- Molecular formula:
- C6H15N3
- IUPAC Name:
- 2-piperazin-1-ylethanamine
- Reference substance name:
- unkown or unassigned - no information on substance identity available
- Molecular formula:
- Not relevant
- IUPAC Name:
- unkown or unassigned - no information on substance identity available
- Test material form:
- liquid: viscous
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Animals were received from Covance Research Products Inc., Denver, PA, on 28 Jun 2017. Following
an acclimation period of at least five days, three healthy New Zealand White rabbits (two males - one
female) were selected from a larger group without conscious bias.
The animals were born on 28 Jan 2017 and 11 Feb 2017. The pre-test body weight range was
2.9 - 3.2 kg.
The animals were identified by cage notation and a uniquely numbered metal ear tag and individually
housed in suspended wire-bottom cages. Absorbent paper bedding was placed beneath the cages and
changed at least three times per week. Fresh PMI Rabbit Chow (Diet No. 5321) was provided daily.
Water was available ad libitum. The animal room, reserved exclusively for rabbits on acute tests, was
temperature controlled, had a 12-hour light/dark cycle, and was kept clean and vermin free.
Test system
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml ot test material
- Duration of treatment / exposure:
- 1h and 4 h
- Observation period:
- 14 days
- Number of animals:
- 4
- Details on study design:
- Site Preparation
Approximately 24 hours prior to application of the test article, the dorsal area of the trunk of each animal
was clipped free of hair. The prepared site was approximately 10% of the body surface and remained
intact.
Dosing
Initially, one rabbit was dosed on Site 1. The test article was dosed by volume, 0.5 ml per site and placed
on top of a 2 x 3 cm gauze patch. Gentle pressure was applied to aid in the distribution of the test article
over the prepared site. The dose patch was secured with non-irritating tape and the rabbit was gently held
in place. The dose patch was removed at 3 minutes post-exposure and the test site was gently washed
with gauze saturated with distilled water following patch removal. The outline of the dose site was
marked using an indelible marker.
Since no evidence of a corrosive or severely irritating effect was observed in the initial animal, two
additional animals were added to the study. All three animals were dosed at Site 2 for an exposure
period of one hour and Site 3 for an exposure period of four hours. The clipped area of the torso was
covered with a piece of porous dressing large enough to cover all dose sites with at least 5 cm2 to spare
on all sides of the gauze patch. Porous, non-irritating tape was used to encircle the trunk of the animal.
After the exposure period, the wrappings and patches were removed and the sites gently washed with
gauze saturated with distilled water. The outline of the dose site was marked using an indelible marker.
Type and Frequency of Observations
Exposure Site 1 of the initial animal was scored for dermal irritation immediately post-exposure and at
one hour post-exposure. Sites 2 (one-hour exposure) and 3 (four-hour exposure) were scored for dermal
irritation at 1, 24, 48 and 72 hours and again on Day 7 after patch removal. Reactions were scored again
on Day 14 for the four-hour exposure. Erythema and edema were scored according to the numerical
Draize1 scale. The skin was also evaluated for ulceration and necrosis or any evidence of tissue
destruction. Additional signs were described.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- > 0 - < 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other:
- Remarks:
- 1 h exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 1 h exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- > 1 - < 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 14 d
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other:
- Remarks:
- 4 h exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- > 1 - < 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 h exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 14 d
- Score:
- > 0 - < 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 4 h exposure
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Skin irritation of 4,4’-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with 3-aminopropyldiethylamine and 2-piperazin-1-ylethylamine was determined to ce GHS category 2 in study with rabbits.
- Executive summary:
Skin irritation of 4,4’-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with 3-aminopropyldiethylamine and 2-piperazin-1-ylethylamine was determined to ce GHS category 2 in study with rabbits.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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