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Diss Factsheets
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EC number: 608-408-6 | CAS number: 29736-24-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 29, 1998 - September 07, 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP-guideline study of a very similar substance (BRUGGOLITE FF6): This study was conducted following OECD-guideline 401. The study was performed in accordance with the principles of GLP (§19a, ChemG). Similarity of BLANCOLEN HP and BLANCOLEN HP BRUGGOLITE FF6 is a multi-constituent substance composed of • Disodium hydroxysulfinateacetate • Disodium hydroxysulfonateacetate • Sodium sulphite (as impurity) BLANCOLEN HP is the mono-constituent substance • Disodium hydroxysulfonateacetate During the manufacturing of BRUGGOLITE FF6 (the desired molecule is disodium hydroxysulfinate-acetate) the formation of disodium hydroxysulfonateacetate cannot be avoided. Sodium sulphite is an impurity resulting from the starting material. BLANCOLE HP can be obtained by a similar reaction as a mono-constituent substance. Especially in aqueous media, disodium hydroxysulfinateacetate of BRUGGOLITE FF6 is easily oxidized; the primarily resulting product is disodium hydroxysulfonateacetate. Therefore, practically no significant differences will occur between testing of BRUGGOLITE FF6 and BLANCOLEN HP in aqueous systems if any contributions of sodium sulphite to the result can be neglected. Moreover disodium hydroxysulfinateacetate is the stronger reducing agent and is expected to induce more severe effects compared to the hydroxysulfonateacetate.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous solution
- Doses:
- 2000 mg/kgbw
- No. of animals per sex per dose:
- 5 males
5 females - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Any other information on results incl. tables
A single dose of the aqueous solution (6 g ad. 30 ml) was administered after an overnight fasting by oral gavage, using a metal catheter and disposable plastic syrings, with a constant volume of 1 ml/100 gbw to each of 5 males and 5 females. Individual doses were adjusted according to the body weight on the day of administration.
No animal died after single oral administration of 2000 mg/kgbw of BRUGGOLITE FF6. The LD50 rat is > 2000 mg/kgbw
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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