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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 208-594-5 | CAS number: 534-22-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Acute oral toxicity
There are 2 studies available in which the oral toxicity is assessed. The study result available in the Quaker Oat bulletin was used to derive the classification, since the data was judged to be more reliable than that of Marhold.
The Quaker Oat bulletin reports a LD50 value of 133 mg/kg bw. According to the EU Regulation No. 1272/2008 on the Classification, Labelling and Packaging of Substances and Mixtures (CLP) the substance should hence be classified as acute toxic via oral route, cat. 3, because the LD50 is in the range of 50 - 300 mg/kg bw (Table 3.1.1).
Acute inhalation toxicity
There are 3 studies available in which the inhalation toxicity is assessed. The most comprehensive and reliable study available is the study by Terril et al. (1989). This study was used to derive the classification.
The Terril et al. study reports a LC50 value of 1488 ppm after 1h exposure. Since it concerns a vapour, this value was divided by 2 to derive the 4h exposure equivalent. The LC50 is hence 742 ppm or 2.48 mg/L. According to the EU Regulation No. 1272/2008 on the Classification, Labelling and Packaging of Substances and Mixtures (CLP) the substance should hence be classified as acute toxic via inhalation, cat. 3, because the LC50 is in the range of 2 - 10 mg/L (Table 3.1.1).
Acute dermal toxicity
There is one study in which the acute toxicity via dermal route has been assessed, i.e. the Quaker Oat bulletin. The reported LD50 value is 1600 mg/kg after 24h exposure to the undiluted substance. According to the EU Regulation No. 1272/2008 on the Classification, Labelling and Packaging of Substances and Mixtures (CLP) the substance should hence be classified as acute toxic via dermal route, cat. 4, because the LD50 is in the range of 1000- 2000 mg/kg bw (Table 3.1.1).
However, it is to be noted that in this study the test material was administered percutaneous. Hence, the reported LD50 value is most likely an overestimation of the toxicity. The classification is hence considered to be conservative.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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