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Diss Factsheets
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EC number: 215-128-4 | CAS number: 1304-29-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as corrosive to the skin
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
According to the annex VII of REACH regulation, under the study under the point 8.5.1 (Acute toxicity by oral route) does not need to be conducted if the substance is classified as corrosive to the skin. An OECD 435 was performed on the substance and the conclusion is that Barium peroxide has to be classified in category 1B. Consequently, a study on acute toxicity is scientifically not necessary.
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 01 MArch to 20 April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source of test material: Bernardy, Barium peroxide, code BAO20
- batch No.: 1704349
- Purity test date: 26/12/2017
- date of reception: 23/01/18
- Expiry date: 26/12/2019
STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature - Test system:
- artificial membrane barrier model
- Justification for test system used:
- Testsystem recommended in the OECD 435 Guideline.
- Vehicle:
- unchanged (no vehicle)
- Details on test system:
- SOURCE AND COMPOSITION OF MEMBRANE BARRIER USED
- Was the Corrositex® test kit used: Yes (In Vitro International supplied by INT.E.G.RA. Srl, batch No. CT100217)
- Components: The test system is composed of two components, a synthetic macromolecular bio-barrier (MEMBRANE DISCS, batch No. CT100217) and a Chemical Detection System (CDS).
- Delivery date: 15/12/2017
- Date of initiation of testing: 01/03/2018
- Apparatus and preparation procedures: Detailed in §4.2.5 of the final report.
WAS THE COMPATIBILITY TEST PERFORMED: Yes
WAS THE TIMESCALE CATEGORY TEST PERFORMED: Yes
TEMPERATURE USED:
- Temperature used during treatment: room temperature
- Temperature during storage: 6°C ± 3°C
METHOD OF DETECTION
- Chemical detection system (CDS) used
METHOD OF APPLICATION:
- 500 mg of test item BARIUM PEROXIDE in quadruplicate,
- 110 ± 15 mg of positive control sodium hydroxide in single,
- and 500 μL of negative control 6% propionic acid solution in single.
NUMBER OF REPLICATES: 4 replicates + 1 positive control + 1 negative control
PREDICTION MODEL / DECISION CRITERIA (choose relevant statement)
- The test substance is considered to be corrosive 1B to skin if the time elapsed between application of the test substance to the membrane barrier and barrier penetration is > 3 to 60 min. - Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- - 500 mg of test item BARIUM PEROXIDE in quadruplicate,
- 110 ± 15 mg of positive control sodium hydroxide in single,
- and 500 μL of negative control 6% propionic acid solution in single. - Duration of treatment / exposure:
- planned to be 240 min
- Number of replicates:
- 4
- Irritation / corrosion parameter:
- penetration time (in minutes)
- Run / experiment:
- 240 min
- Value:
- 30.83
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- In accordance with the Regulation EC No. 1272/2008, the results obtained under these experimental conditions enable to conclude that the test item BARIUM PEROXIDE has to be classified in Category 1B “Corrosive” and the UN Packaging group II is required.
The hazard statements “H314: Causes severe skin burns and eye damage” with the signal word “Danger” are required. - Executive summary:
The aim of the study was to evaluate the possible effects of the test item BARIUM PEROXIDE after deposition on a synthetic proteinaceous bio-barrier and monitoring using a Chemical Detection System (CDS).
The test item BARIUM PEROXIDE was applied as supplied, at the dose of 500 mg, onto 4 synthetic proteinaceous bio-barriers. Timescale Category Test showed that the test item belongs to Corrositex Category 1.
The experimental protocol was established in accordance withO.E.C.D. Test Guideline No. 435 adopted 28 July 2015.
The test item disrupted the membrane after 30 minutes and 50 seconds.
As expected, the negative control (propionic acid 6% (v/v)) did not disrupt the membrane and was not corrosive.
As expected, the positive control (sodium hydroxide) was found to be corrosive (GHS subcategory 1B) and disrupt the membrane after 19 minutes and 31 seconds.
In accordance with the Regulation EC No. 1272/2008, the results obtained under these experimental conditions enable to conclude that the test itemBARIUM PEROXIDE has to be classified in Category 1B “Corrosive” and the UN Packaging group IIis required.
The hazard statements “H314: Causes severe skin burns and eye damage” with the signal word “Danger” are required.
|
Corrositex time (hr:min:sec) |
||
Corrositex Category : 1 |
Test item |
Positive control |
Negative control |
Replicate 1 |
0:43:32 |
0:19:31 |
>1:00:00 |
Replicate 2 |
0:39:20 |
||
Replicate 3 |
0:16:37 |
||
Replicate 4 |
0:23:51 |
||
Mean |
0:30:50 |
||
Standard deviation |
0:12:42 |
||
CLASSIFICATION in accordance with GHS subcategories |
According to the calculated means, the test item has to be classified in Category 1B |
||
UN Packing Group required |
UN Packing Group II |
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.