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Diss Factsheets
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EC number: 202-809-6 | CAS number: 100-00-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- : only males were tested, no pathologic examination was performed, lack of details on test substance
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-chloro-4-nitrobenzene
- EC Number:
- 202-809-6
- EC Name:
- 1-chloro-4-nitrobenzene
- Cas Number:
- 100-00-5
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-4-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 1-chloro-4-nitrobenzene
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Age at study initiation: no data
- Weight at study initiation: 180-200 g
- Fasting period before study: no data
- Housing: 5 per cage
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- polyethylene glycol
- Details on dermal exposure:
- Dermal application according to the method of Noakes and Sanderson, Brit. J. Industr. Med. 26, 1969, 59
Observation time: 14 days - Duration of exposure:
- 24 hours
- Doses:
- 500, 600, 700, 900, 1000, 1200 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 750 mg/kg bw
- Mortality:
- 600 mg/kg: 2 of 10 3 days after application
700 mg/kg: 5 of 10 3-4 days after application
900 mg/kg: 8 of 10 3-4 days after application
1000 mg/kg: 8 of 10 3-4 days after application
1200 mg/kg: 10 of 10 3h-3 days after application - Clinical signs:
- other: sedation, cyanotic appearance, unkempt fur, palmospasm, low body temperature
- Gross pathology:
- not examined
Any other information on results incl. tables
Acute dermal toxicity of p-nitrochlorobenzene in rats
Dose (mg/kg bw) |
Time of death |
Dead |
Symptoms |
Number of rats used |
500 600 700 900 1000 1200 |
- 3d 3-4d 3-4d 3-4d 3h-2d |
0 2 5 8 8 10 |
10 10 10 10 10 10 |
10 10 10 10 10 10 |
Value: (670 - 830 mg/kg bw)
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Classification:
DSD: Xn, R21 Harmful in contact with skin
GHS: Acute Dermal Category 3 H311 - Executive summary:
Loeser, Bayer AG, 1979
The study was performed comparable to guideline study 402 with acceptable restrictions (no pathologic examination was performed, lack of details on test substance). The acute dermal toxicity of 1-chloro-4-nitrobenzene was investigated in 10 male rats per dose according to the method of Noakes and Sanderson, 1969. The animals were dosed with 500, 600, 700, 900, 1000, 1200 mg/kg body weight. Sedation, cyanotic appearance, unkempt fur, palmospasm, low body temperature were observed at dose levels equal to and exceeding 600 mg/kg body weight. The LD50 was 750 mg/kg body weight.
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