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Diss Factsheets
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EC number: 219-698-5 | CAS number: 2499-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VII
- Author:
- Smyth HF, Carpenter CP, Carrol SW, Urbano CP, Streigel JA, Nycum JS
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. Vol 30, 470-476
Materials and methods
- Principles of method if other than guideline:
- Eye injury in rabbits is recorded in a 10 grade ordinal series and is based upon the degree of corneal necrosis that results from single instillation of 0.5 ml undiluted test substance into conjunctival sac of 5 rabbits. Read immediately unstained and after fluoroscein at 24 hours, with ten grades recognized
- GLP compliance:
- no
- Remarks:
- Study predates GLP
Test material
- Reference substance name:
- Hexyl acrylate
- EC Number:
- 219-698-5
- EC Name:
- Hexyl acrylate
- Cas Number:
- 2499-95-8
- Molecular formula:
- C9H16O2
- IUPAC Name:
- hexyl prop-2-enoate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source:
- Age at study initiation:
- Weight at study initiation:
- Housing:
- Diet (e.g. ad libitum):
- Water (e.g. ad libitum):
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light):
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- Duration of treatment: 24 h
- Number of animals or in vitro replicates:
- 5 Rabbits
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no washing
- Time after start of exposure:
SCORING SYSTEM: Grade 1 indicates at most a very small areas of necrosis resulting from 0.5 mL undiluted chemical in the eye. Grade 5 indicates a severe burn from 0.005 mL undiluted and Grade 10 indicates a severe burn from 0.5 mL of a 1% solution in water or propylene glycol.
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Irritation grade based on Carpenter et al. (1946)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Grade 1.0 corresponds to Necrosis on less than 5% of cornea
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Based on the irritation score of Grade 1.0, which corresponds to Necrosis on less than 5% of cornea, n-hexyl acrylate is considered irritating to the eye.
- Executive summary:
N-hexyl Acrylate produced evidence of eye irritation in an in-vivo rabbit assay. This finding supports classification of N-hexyl Acrylate as a Category 2 Eye Irritant under the Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP).
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