Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-387-7 | CAS number: 27287-73-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- No formal claim. Study conducted in a facility operating to GLP.
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- -0.6
- Temp.:
- 20 °C
- pH:
- 5
- Key result
- Type:
- log Pow
- Partition coefficient:
- -0.97
- Temp.:
- 20 °C
- pH:
- 7
- Type:
- log Pow
- Partition coefficient:
- -2.6
- Temp.:
- 20 °C
- pH:
- 9
- Details on results:
- The individual log Pow values of the six samples in each solution clearly fall within the requirement of +/- 0.3 log units.
- Conclusions:
- At all pH values and at 20 °C, the octanol / water partition coefficient has been determined
experimentally to be:
log Pow = -0.60 at pH 5.0
log Pow = -0.97 at pH 7.0
log Pow = -2.6 at pH 9.0 - Executive summary:
The 1-octanol / water partition coefficient ( Pow ) of the test substance has been determined at 20 °C in accordance with the EU method A.8., the OECD guideline number 107 and the EPA test guideline OPPTS 830.7550 using the shake-flask method. The results are summarized below:
Pow = 0.25 (+/- 0.0039) log Pow = -0.60 at pH 5.0
Pow = 0.11 (+/- 0.0011) log Pow = -0.97 at pH 7.0
Pow = 0.0024 (+/- 0.000041) log Pow = -2.6 at pH 9.0
log Pow is the logarithm to base 10 of Pow
The figure in parentheses represents one standard deviation about the mean and the final values have been quoted correct to two significant figures.
Reference
Description of key information
At all pH values and at 20 °C, the octanol / water partition coefficient has been determined experimentally to be:
log Pow = -0.60 at pH 5.0
log Pow = -0.97 at pH 7.0
log Pow = -2.6 at pH 9.0
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.97
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
