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EC number: 271-685-3 | CAS number: 68604-33-1 This substance is identified by SDA Substance Name: C14-C18 and C16-C18 unsaturated alkyl carboxylic acid ammonium salt and SDA Reporting Number: 04-006-01.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not given
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- Fatty acids, C16-18 and C18-unsatd.
- EC Number:
- 266-932-7
- EC Name:
- Fatty acids, C16-18 and C18-unsatd.
- Cas Number:
- 67701-08-0
- Details on test material:
- Mixture of carboxylic acids (fatty acids C14-18), ceraceous, yellowish; by heating to 50 ° C quickly liquefiable
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
2 groups with 5 male and female rats each.
- Source: raiser: Winkelmann, Hannover.
- Weight at study initiation: 168g (male rats), 143g (female rats).
- Fasting period before study: 18 hours
- Housing: 5 animals per cage, separated by sexes.
- Diet: laboratory standard diet (altromin) and water water ad libitum.
The test animals were provided food (ad libitum) 3 hours after application.
ENVIRONMENTAL CONDITIONS
- Temperature: 22°C;
- Humidity (%): 45-60%;
- Air changes (per hr): not given;
- Photoperiod (hrs dark / hrs light): 12 hours.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 25% aqueous suspension
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25%;
- Amount of vehicle (if gavage): 20ml/kg.
MAXIMUM DOSE VOLUME APPLIED: 5g/kg.
DOSAGE PREPARATION (if unusual): for preparation of the suspention were used lukewarm aqua dest.. The supension was kept in movement with magnetic stirrer for applying an even mixed suspension to the test animals.
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: Based on chemical composition a less acute toxicity of the test item was expected. Because of that a limit test with a dosis of 5g/kg body weight was proved. - Doses:
- 5 g/kg bw
- No. of animals per sex per dose:
- 10 animals per dose including both male and female animals
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days;
- Frequency of observations and weighing: daily observations;
- Necropsy of survivors performed: yes;
Other examinations performed: clinical signs, body weight.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All 10 rats survived the 14 days of observation.
- Clinical signs:
- No symptoms of poisoning were found during the observation.
- Body weight:
- see table below.
- Gross pathology:
- No symptoms of poisoning or inflammations neither on the inner organs nor the visceral cavities were found.
Any other information on results incl. tables
Body weight average in g of each 5 test animals before and after application:
dose |
sex |
before application |
24 h after application |
7 d after application |
14 d after application |
5 g/kg |
male | 168.0 | 180.0 | 202.0 | 218.0 |
5 g/kg | female | 143.0 | 152.0 | 159.0 | 164.0 |
As its seen in the table the application of 5 g/kg had no impact on the body weight progress of the test animals.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item proves to be low acute toxicity. The LD50 can be declared for male and female rats: >5 g/kg.
- Executive summary:
The carboxylic acid Edenor Ti (Edenor Talg A) was tested for acute oral toxicity according to OECD guidline 401 by limit test. It was proved to be less acute toxic at peroral application on rats (LD50 >5 g/kg bw).
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