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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 236-195-6 | CAS number: 13223-03-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Test material form:
- liquid
- Details on test material:
- METHACRYLOYLDIMETHYLETHYLAMMONIUMETHYLSULFATE, 39 .6% AQUEOUS FORMULATION
SUBSTANCE NUMBER: 94/521
LOT NUMBER: PARTIE 7/94
DATE OF MANUFACTURING: 10-SEP-1994
PHYSICAL STATE/APPEARANCE : LIQUID, ACHROMATIC
Constituent 1
- Specific details on test material used for the study:
- METHACRYLOYLDIMETHYLETHYLAMMONIUMETHYLSULFATE, 39 .6% AQUEOUS FORMULATION
SUBSTANCE NUMBER: 94/521
LOT NUMBER: PARTIE 7/94
DATE OF MANUFACTURING: 10-SEP-1994
PHYSICAL STATE/APPEARANCE : LIQUID, ACHROMATIC
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- ANIMAL SPECIES: RABBIT / WHITE NEW ZEALAND (SPF)
ANIMAL SUPPLIER: DR. K. THOMAE GMBH, BIBERACH, FRG
AGE OF THE ANIMALS: YOUNG ADULT ANIMALS
ANIMAL IDENTIFICATION: EAR TATTOO
ROOM TEMPERATURE/ RELATIVE HUMIDITY: THE ANIMALS WERE HOUSED IN FULLY AIR-CONDITIONED ROOMS. CENTRAL AIR-CONDITIONING GUARANTEED A RAN GE OF 20 - 24 DEGREES CELSIUS FOR TEMPERATURE AND OF 30 - 70 % FOR RELATIVE HUMIDITY.THERE WERE NO DEVIATIONS FROM THESE RANGES WHICH INFLUENCED THE RESULTS OF THE STUDY.
DAY/NIGHT RHYTHM: 12 H/12 H (6.00 A.M. - 6.00 P.M./ 6.00 P.M. - 6.00 A.M. )
TYPE OF CAGE: STAINLESS STEEL WIRE MESH CAGES WITH GRATING, FLOOR AREA : 3000 CM2
NO. OF ANIMALS PER CAGE: SINGLE HOUSING
BEDDING: NO BEDDING IN THE CAGES; SAWDUST IN THE WASTE TRAYS
DRINKING WATER: ABOUT 250 ML TAP WATER PER ANIMAL PER DAY
DIET: KLIBA-LABORDIAET 341, KLINGENTALMUEHLE AG KAISERAUGST, SWITZERLAND (ABOUT 130 G PER ANIMAL PER DAY)
ANALYSIS OF DRINKING WATER: THE DRINKING WATER IS REGULARLY ASSAYED FOR CHEMICAL CONTAMINANTS BY THE MUNICIPAL AUTHORI TIES OF FRANKENTHAL ANO THE TECHNICAL SERVICES OF BASF AKTIENGESELLS CHAFT AS WELL AS FOR THE PRESENCE OF GERMS BY A CONTRACT LABORATORY.
ANALYSIS OF FEED: THE FEED USED IN THE STUDY WAS ASSAYED FOR CHEMICAL ANO MICROBIOLOGICAL CONTAMINANTS.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Total quantity applied: 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1h, 24 h, 48 h and 72 hours after the patch removal.
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: dorsal/flank area
- Type of wrap if used: The test substance has been covered with a test patch and Fixomull stretch adhesive fleece.
REMOVAL OF TEST SUBSTANCE: residual is wiped with a cotton wool soaked in water.
SCORING SYSTEM: Draize's score
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 0.1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no effect observed
- Irritant / corrosive response data:
- In the first 24 hours only erythema was observed and in only 1 animal (score = 1). Subsequently no effects were observed.
- Other effects:
- None.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the test, MADQUAT DES is not irritating to the skin of the rabbit.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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