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Diss Factsheets
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EC number: 234-634-6 | CAS number: 12018-10-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Guideline skin and eye irritation compliant studies are available for 'Chromoxyd Dyko' (containing 96% chromium oxide and 4% titanium dioxide) (Martins, 1988). Additional supporting studies have been performed using 'Chromoxid Grun GN' (chromium oxide) (Mihail, 1977) and 'Chromoxid grun Extra (chromium hydroxide) (Thyssen, 1979).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin and eye irritation
The studies performed using 'Chromoxid Dyko' (96% chromium oxide, 4% titanium oxide) are compliant with GLP and appropriate guidelines (Martins, 1988). These studies show that the test material was non-irritating to skin and was a minimal eye irritant. Titanium dioxide is known to be toxicologically inert, therefore the results of these studies can be relied upon. The studies performed using chromium oxide ('Chromoxid Grun GN') were not performed to any guideline (Mihail, 1977), but show consistent results of no skin irritation and minimal, reversible eye irritation. Similarly, the studies performed using the related compound chromium hydroxide (Thyssen, 1979) show an absence of skin and eye irritation.
It can therefore be concluded that chromium oxide is not classifiable for skin or eye irritation according to current EU criteria. No further testing is required.
Respiratory irritation
No studies have been performed. There is no indication from the physicochemical properties, from the available animal studies or from human experience of use, that chromium oxide is a respiratory irritant.
Justification for classification or non-classification
The absence of skin irritation and the minimal, reversible eye irritation seen in the studies discussed above show that chromium oxide is not classified for skin or eye irritation according to current EU criteria.
In the absence of any indication of respiratory irrittaion from the physicochemical properties, from the available animal studies or from human experience of use, it is not proposed to classify chromium oxide as a respiratory irritant.
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